Depletion of blood neutrophils from patients with sepsis: Treatment for the future?

Sion M. Lewis, Nahida Khan, Richard Beale, David F Treacher, K. Alun Brown*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)

Abstract

Organ failure arising from severe sepsis accounts for nearly 6 million deaths worldwide per annum. At present there are no specific pharmacological agents available for its treatment and identifying a suitable therapeutic target is urgently needed. Neutrophils appear to be contributing directly to pulmonary damage in severe forms of lung injury and indirectly to the failure of other organs. Blood neutrophils from patients with sepsis possess a phenotype that is indicative of activation and our results show that neutrophils isolated from patients with sepsis exhibit a supranormal adherence to endothelial monolayers treated with pro-inflammatory cytokines. Additional studies reveal that the patients' cells are highly efficient at releasing IL-8. We also demonstrate that organ function is improved upon removing neutrophils from the circulation. In this article we propose that in severe sepsis there is a subpopulation of neutrophils which is actively engaged in pathological insult. The phenotypic characterisation of this subset may provide a novel therapeutic strategy for sepsis that could lead to patient benefit.

Original languageEnglish
Pages (from-to)1226-1232
Number of pages7
JournalINTERNATIONAL IMMUNOPHARMACOLOGY
Volume17
Issue number4
DOIs
Publication statusPublished - 1 Dec 2013

Keywords

  • adherence
  • cytokines
  • leukofiltration
  • Neutrophils
  • sepsis

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