Depot testosterone with etonogestrel implants result in induction of azoospermia in all men for long-term contraception

TY - JOUR

T1 - Depot testosterone with etonogestrel implants result in induction of azoospermia in all men for long-term contraception

AU - Brady, B M

AU - Walton, M

AU - Hollow, N

AU - Kicman, A T

AU - Baird, D T

AU - Anderson, R A

PY - 2004/11

Y1 - 2004/11

N2 - Background: Combined testosterone and progestogen preparations are a promising approach to male hormonal contraception. We investigated the effect of s.c. etonogestrel with depot testosterone on spermatogenesis in normal men over a period of 48 weeks. Methods: Fifteen healthy men received three s.c. 68 mg etonogestrel implants. Testosterone pellets (400 mg) were administered at 12 weekly intervals. Results: Nine men completed 48 weeks of treatment. Four subjects chose to discontinue after 6 months, one man withdrew from the study early for personal reasons and one was withdrawn due to illness. Sperm concentrations of

AB - Background: Combined testosterone and progestogen preparations are a promising approach to male hormonal contraception. We investigated the effect of s.c. etonogestrel with depot testosterone on spermatogenesis in normal men over a period of 48 weeks. Methods: Fifteen healthy men received three s.c. 68 mg etonogestrel implants. Testosterone pellets (400 mg) were administered at 12 weekly intervals. Results: Nine men completed 48 weeks of treatment. Four subjects chose to discontinue after 6 months, one man withdrew from the study early for personal reasons and one was withdrawn due to illness. Sperm concentrations of

UR - http://www.scopus.com/inward/record.url?scp=8344236641&partnerID=8YFLogxK

U2 - 10.1093/humrep/deh491

DO - 10.1093/humrep/deh491

M3 - Article

SN - 1460-2350

VL - 19

SP - 2658

EP - 2667

JO - Human Reproduction

JF - Human Reproduction

IS - 11

ER -