Depression and anxiety in patients receiving interferon-alpha: the role of illness perceptions

Nilay Hepgul; Carmine Maria Pariante; Sara Baraldi; Alessandra Borsini; Chiara Bufalino; Alice Elizabeth Russell; Kosh Agarwal; Anthony James Cleare; Daniel M Forton; Max Joseph Henderson; Valeria Mondelli; Gopinath Ranjith; Matthew Hugo Hotopf

doi:10.1177/1359105316658967

Depression and anxiety in patients receiving interferon-alpha: the role of illness perceptions

Nilay Hepgul, Carmine Maria Pariante, Sara Baraldi, Alessandra Borsini, Chiara Bufalino, Alice Elizabeth Russell, Kosh Agarwal, Anthony James Cleare, Daniel M Forton, Max Joseph Henderson, Valeria Mondelli, Gopinath Ranjith, Matthew Hugo Hotopf

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Abstract

Development of psychiatric symptoms during interferon-alpha (IFN-α) therapy may be influenced by psychological factors. We examined illness perceptions using The Revised Illness Perceptions Questionnaire (IPQ-R) in 55 patients with chronic Hepatitis C virus infection, due to receive IFN-α. The Hospital Anxiety and Depression Scale (HADS) was used to assess the development of symptoms. Negative identity, consequences and emotional representations beliefs were significantly associated with both higher depression and anxiety scores. Negative illness perceptions play a predictive role in the development of IFN-α-induced psychiatric symptoms.

Original language	English
Pages (from-to)	1405-1414
Journal	Journal of Health Psychology
Volume	23
Issue number	11
Early online date	24 Jul 2016
DOIs	https://doi.org/10.1177/1359105316658967
Publication status	E-pub ahead of print - 24 Jul 2016

Keywords

DEPRESSION
ANXIETY
ILLNESS PERCEPTIONS
INTERFERON
HEPATITIS-C

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Depression and anxiety in patients_HEPGUL_Accepted14June2016_GREEN AAMAccepted author manuscript, 555 KB

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Hepgul, N., Pariante, C. M., Baraldi, S., Borsini, A., Bufalino, C., Russell, A. E., Agarwal, K., Cleare, A. J., Forton, D. M., Henderson, M. J., Mondelli, V., Ranjith, G., & Hotopf, M. H. (2016). Depression and anxiety in patients receiving interferon-alpha: the role of illness perceptions. Journal of Health Psychology, 23(11), 1405-1414. Advance online publication. https://doi.org/10.1177/1359105316658967

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abstract = "Development of psychiatric symptoms during interferon-alpha (IFN-α) therapy may be influenced by psychological factors. We examined illness perceptions using The Revised Illness Perceptions Questionnaire (IPQ-R) in 55 patients with chronic Hepatitis C virus infection, due to receive IFN-α. The Hospital Anxiety and Depression Scale (HADS) was used to assess the development of symptoms. Negative identity, consequences and emotional representations beliefs were significantly associated with both higher depression and anxiety scores. Negative illness perceptions play a predictive role in the development of IFN-α-induced psychiatric symptoms.",

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AU - Borsini, Alessandra

AU - Bufalino, Chiara

AU - Russell, Alice Elizabeth

AU - Agarwal, Kosh

AU - Cleare, Anthony James

AU - Forton, Daniel M

AU - Henderson, Max Joseph

AU - Mondelli, Valeria

AU - Ranjith, Gopinath

AU - Hotopf, Matthew Hugo

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AB - Development of psychiatric symptoms during interferon-alpha (IFN-α) therapy may be influenced by psychological factors. We examined illness perceptions using The Revised Illness Perceptions Questionnaire (IPQ-R) in 55 patients with chronic Hepatitis C virus infection, due to receive IFN-α. The Hospital Anxiety and Depression Scale (HADS) was used to assess the development of symptoms. Negative identity, consequences and emotional representations beliefs were significantly associated with both higher depression and anxiety scores. Negative illness perceptions play a predictive role in the development of IFN-α-induced psychiatric symptoms.

KW - DEPRESSION

KW - ANXIETY

KW - ILLNESS PERCEPTIONS

KW - INTERFERON

KW - HEPATITIS-C

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DO - 10.1177/1359105316658967

M3 - Article

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EP - 1414

JO - Journal of Health Psychology

JF - Journal of Health Psychology

IS - 11

ER -

Depression and anxiety in patients receiving interferon-alpha: the role of illness perceptions

Abstract

Keywords

UN SDGs

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