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Depression comorbid with tuberculosis and its impact on health status: cross-sectional analysis of community-based data from 48 low- and middle-income countries

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Depression comorbid with tuberculosis and its impact on health status : cross-sectional analysis of community-based data from 48 low- and middle-income countries. / Koyanagi, Ai; Vancampfort, Davy; Carvalho, André F; DeVylder, Jordan E; Haro, Josep Maria; Pizzol, Damiano; Veronese, Nicola; Stubbs, Brendon.

In: BMC Medicine, Vol. 15, 209, 28.11.2017.

Research output: Contribution to journalArticle

Harvard

Koyanagi, A, Vancampfort, D, Carvalho, AF, DeVylder, JE, Haro, JM, Pizzol, D, Veronese, N & Stubbs, B 2017, 'Depression comorbid with tuberculosis and its impact on health status: cross-sectional analysis of community-based data from 48 low- and middle-income countries', BMC Medicine, vol. 15, 209. https://doi.org/10.1186/s12916-017-0975-5

APA

Koyanagi, A., Vancampfort, D., Carvalho, A. F., DeVylder, J. E., Haro, J. M., Pizzol, D., ... Stubbs, B. (2017). Depression comorbid with tuberculosis and its impact on health status: cross-sectional analysis of community-based data from 48 low- and middle-income countries. BMC Medicine, 15, [209]. https://doi.org/10.1186/s12916-017-0975-5

Vancouver

Koyanagi A, Vancampfort D, Carvalho AF, DeVylder JE, Haro JM, Pizzol D et al. Depression comorbid with tuberculosis and its impact on health status: cross-sectional analysis of community-based data from 48 low- and middle-income countries. BMC Medicine. 2017 Nov 28;15. 209. https://doi.org/10.1186/s12916-017-0975-5

Author

Koyanagi, Ai ; Vancampfort, Davy ; Carvalho, André F ; DeVylder, Jordan E ; Haro, Josep Maria ; Pizzol, Damiano ; Veronese, Nicola ; Stubbs, Brendon. / Depression comorbid with tuberculosis and its impact on health status : cross-sectional analysis of community-based data from 48 low- and middle-income countries. In: BMC Medicine. 2017 ; Vol. 15.

Bibtex Download

@article{3848bc81dc4941a0a66bc1c9181be8f0,
title = "Depression comorbid with tuberculosis and its impact on health status: cross-sectional analysis of community-based data from 48 low- and middle-income countries",
abstract = "BACKGROUND: Depression in tuberculosis increases the risk for adverse health outcomes. However, little is known about comorbid depression and tuberculosis in the general population. Thus, we assessed the association between depression and tuberculosis, and the decrements in health status associated with this comorbidity in 48 low- and middle-income countries.METHODS: Cross-sectional, community-based data from the World Health Survey on 242,952 individuals aged ≥ 18 years were analyzed. Based on the World Mental Health Survey version of the Composite International Diagnostic Interview, past 12-month depression was categorized into depressive episode, brief depressive episode, subsyndromal depression, and no depression. Health status across six domains (cognition, interpersonal activities, sleep/energy, self-care, mobility, pain/discomfort) was assessed. Multivariable logistic and linear regression analyses were performed to assess the associations.RESULTS: The prevalence of depressive episode among those with and without tuberculosis was 23.7{\%} and 6.8{\%}, respectively (P < 0.001). Tuberculosis was associated with a 1.98 (95{\%} CI 1.47-2.67), 1.75 (95{\%} CI 1.26-2.42), and 3.68 (95{\%} CI 3.01-4.50) times higher odds for subsyndromal depression, brief depressive episode, and depressive episode, respectively. Depressive episode co-occurring with tuberculosis was associated with significantly worse health status across all six domains compared to tuberculosis alone. Interaction analysis showed that depression significantly amplifies the association between TB and difficulties in self-care but not in other health domains.CONCLUSIONS: Depression is highly prevalent in adults with tuberculosis, and is associated with worse health status compared to tuberculosis without depression. Public health efforts directed to the recognition and management of depression in people with tuberculosis may lead to better outcomes.",
author = "Ai Koyanagi and Davy Vancampfort and Carvalho, {Andr{\'e} F} and DeVylder, {Jordan E} and Haro, {Josep Maria} and Damiano Pizzol and Nicola Veronese and Brendon Stubbs",
year = "2017",
month = "11",
day = "28",
doi = "10.1186/s12916-017-0975-5",
language = "English",
volume = "15",
journal = "BMC Medicine",
issn = "1741-7015",
publisher = "BIOMED CENTRAL LTD",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Depression comorbid with tuberculosis and its impact on health status

T2 - cross-sectional analysis of community-based data from 48 low- and middle-income countries

AU - Koyanagi, Ai

AU - Vancampfort, Davy

AU - Carvalho, André F

AU - DeVylder, Jordan E

AU - Haro, Josep Maria

AU - Pizzol, Damiano

AU - Veronese, Nicola

AU - Stubbs, Brendon

PY - 2017/11/28

Y1 - 2017/11/28

N2 - BACKGROUND: Depression in tuberculosis increases the risk for adverse health outcomes. However, little is known about comorbid depression and tuberculosis in the general population. Thus, we assessed the association between depression and tuberculosis, and the decrements in health status associated with this comorbidity in 48 low- and middle-income countries.METHODS: Cross-sectional, community-based data from the World Health Survey on 242,952 individuals aged ≥ 18 years were analyzed. Based on the World Mental Health Survey version of the Composite International Diagnostic Interview, past 12-month depression was categorized into depressive episode, brief depressive episode, subsyndromal depression, and no depression. Health status across six domains (cognition, interpersonal activities, sleep/energy, self-care, mobility, pain/discomfort) was assessed. Multivariable logistic and linear regression analyses were performed to assess the associations.RESULTS: The prevalence of depressive episode among those with and without tuberculosis was 23.7% and 6.8%, respectively (P < 0.001). Tuberculosis was associated with a 1.98 (95% CI 1.47-2.67), 1.75 (95% CI 1.26-2.42), and 3.68 (95% CI 3.01-4.50) times higher odds for subsyndromal depression, brief depressive episode, and depressive episode, respectively. Depressive episode co-occurring with tuberculosis was associated with significantly worse health status across all six domains compared to tuberculosis alone. Interaction analysis showed that depression significantly amplifies the association between TB and difficulties in self-care but not in other health domains.CONCLUSIONS: Depression is highly prevalent in adults with tuberculosis, and is associated with worse health status compared to tuberculosis without depression. Public health efforts directed to the recognition and management of depression in people with tuberculosis may lead to better outcomes.

AB - BACKGROUND: Depression in tuberculosis increases the risk for adverse health outcomes. However, little is known about comorbid depression and tuberculosis in the general population. Thus, we assessed the association between depression and tuberculosis, and the decrements in health status associated with this comorbidity in 48 low- and middle-income countries.METHODS: Cross-sectional, community-based data from the World Health Survey on 242,952 individuals aged ≥ 18 years were analyzed. Based on the World Mental Health Survey version of the Composite International Diagnostic Interview, past 12-month depression was categorized into depressive episode, brief depressive episode, subsyndromal depression, and no depression. Health status across six domains (cognition, interpersonal activities, sleep/energy, self-care, mobility, pain/discomfort) was assessed. Multivariable logistic and linear regression analyses were performed to assess the associations.RESULTS: The prevalence of depressive episode among those with and without tuberculosis was 23.7% and 6.8%, respectively (P < 0.001). Tuberculosis was associated with a 1.98 (95% CI 1.47-2.67), 1.75 (95% CI 1.26-2.42), and 3.68 (95% CI 3.01-4.50) times higher odds for subsyndromal depression, brief depressive episode, and depressive episode, respectively. Depressive episode co-occurring with tuberculosis was associated with significantly worse health status across all six domains compared to tuberculosis alone. Interaction analysis showed that depression significantly amplifies the association between TB and difficulties in self-care but not in other health domains.CONCLUSIONS: Depression is highly prevalent in adults with tuberculosis, and is associated with worse health status compared to tuberculosis without depression. Public health efforts directed to the recognition and management of depression in people with tuberculosis may lead to better outcomes.

U2 - 10.1186/s12916-017-0975-5

DO - 10.1186/s12916-017-0975-5

M3 - Article

C2 - 29179720

VL - 15

JO - BMC Medicine

JF - BMC Medicine

SN - 1741-7015

M1 - 209

ER -

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