Depression, stress and the adrenal axis

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191 Citations (Scopus)

Abstract

Depression is characterized by an over activity of the hypothalamic-pituitary-adrenal (HPA) axis that resembles the neuroendocrine response to stress. These HPA axis abnormalities participate in the development of depressive symptoms. Moreover, antidepressants directly regulate HPA axis function. These novel findings are reshaping our understanding of the causes and treatment of this disabling disorder.
Original languageEnglish
Pages (from-to)811 - 812
Number of pages2
JournalJournal of Neuroendocrinology
Volume15
Issue number8
Publication statusPublished - 1 Aug 2003

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