Derivative Scores from Site Accessibility and Ranking of miRNA Target Predictions

Abu Dayem Ullah, Saddichha Sahoo, Kathleen Steinhofel, A.A Albrecht

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

In the present study, we define derivative scoring functions from PITA and STarMir predictions. The scoring functions are evaluated for up to five selected miRNAs with a relatively large number of validated targets reported by TarBase and miRecords. The average ranking of validated targets returned by PITA and STarMir is compared to the average ranking produced by the new derivatives scores. We obtain an average improvement of 13.6% (STD∼5.7%) relative to the average ranking of validated targets produced by PITA and STarMir.
Original languageEnglish
Pages (from-to)171-191
Number of pages21
JournalInternational Journal of Bioinformatics Research and Applications
Volume8
Issue number3-4
Early online date7 Sept 2012
DOIs
Publication statusPublished - Sept 2012

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