Derivative Scores from Site Accessibility and Ranking of miRNA Target Predictions

TY - JOUR

T1 - Derivative Scores from Site Accessibility and Ranking of miRNA Target Predictions

AU - Dayem Ullah, Abu

AU - Sahoo, Saddichha

AU - Steinhofel, Kathleen

AU - Albrecht, A.A

PY - 2012/9

Y1 - 2012/9

N2 - In the present study, we define derivative scoring functions from PITA and STarMir predictions. The scoring functions are evaluated for up to five selected miRNAs with a relatively large number of validated targets reported by TarBase and miRecords. The average ranking of validated targets returned by PITA and STarMir is compared to the average ranking produced by the new derivatives scores. We obtain an average improvement of 13.6% (STD∼5.7%) relative to the average ranking of validated targets produced by PITA and STarMir.

AB - In the present study, we define derivative scoring functions from PITA and STarMir predictions. The scoring functions are evaluated for up to five selected miRNAs with a relatively large number of validated targets reported by TarBase and miRecords. The average ranking of validated targets returned by PITA and STarMir is compared to the average ranking produced by the new derivatives scores. We obtain an average improvement of 13.6% (STD∼5.7%) relative to the average ranking of validated targets produced by PITA and STarMir.

U2 - 10.1504/IJBRA.2012.048966

DO - 10.1504/IJBRA.2012.048966

M3 - Article

SN - 1744-5485

VL - 8

SP - 171

EP - 191

JO - International Journal of Bioinformatics Research and Applications

JF - International Journal of Bioinformatics Research and Applications

IS - 3-4

ER -