Deriving Spinal Cord Permeability and Porosity Using Diffusion-Weighted MRI Data

TY - CHAP

T1 - Deriving Spinal Cord Permeability and Porosity Using Diffusion-Weighted MRI Data

AU - Venton, Jenny

AU - Bouyagoub, Samira

AU - Harris, Paul

AU - Phillips, Gary

PY - 2017/7/6

Y1 - 2017/7/6

N2 - A non-invasive technique for deriving permeability and porosity values for spinal cord tissue is described. Poroelastic models of the spinal cord are becoming increasingly important in a range of research areas such as drug delivery and disease. Physical properties of the spinal cord are difficult to obtain due to the complex nature of biological tissues. Neurite orientation dispersion and density imaging (NODDI) is a popular diffusion-weighted MRI technique designed to reveal the microstructure of central nervous system tissues. This microstructural information is used to calculate permeability and porosity values for spinal cord tissue. Permeability values for grey matter were found to be approximately ∼2 × 10−13 m2, whilst for white matter permeability values were in the region of ∼5 × 10−14 m2 perpendicular to tissue fibres and ∼2.5 × 10−13 m2 parallel to tissue fibres. Spinal cord permeability and porosity properties obtained are suitable for use in poroelastic models of the spinal cord.

AB - A non-invasive technique for deriving permeability and porosity values for spinal cord tissue is described. Poroelastic models of the spinal cord are becoming increasingly important in a range of research areas such as drug delivery and disease. Physical properties of the spinal cord are difficult to obtain due to the complex nature of biological tissues. Neurite orientation dispersion and density imaging (NODDI) is a popular diffusion-weighted MRI technique designed to reveal the microstructure of central nervous system tissues. This microstructural information is used to calculate permeability and porosity values for spinal cord tissue. Permeability values for grey matter were found to be approximately ∼2 × 10−13 m2, whilst for white matter permeability values were in the region of ∼5 × 10−14 m2 perpendicular to tissue fibres and ∼2.5 × 10−13 m2 parallel to tissue fibres. Spinal cord permeability and porosity properties obtained are suitable for use in poroelastic models of the spinal cord.

U2 - 10.1061/9780784480779

DO - 10.1061/9780784480779

M3 - Conference paper

BT - Poromechanics VI: Proceedings of the Sixth Biot Conference on Poromechanics

A2 - Vandamme, Matthieu

A2 - Dangla, Patrick

A2 - Pereira, Jean-Michel

A2 - Ghabezloo, Siavash

PB - American Society of Civil Engineers (ASCE)

ER -