Design and synthesis of novel 18F-radiolabelled glucosamine derivatives for cancer imaging

L. Carroll; Timothy H. Witney; E.O. Aboagye

doi:10.1039/c3md00023k

Design and synthesis of novel 18F-radiolabelled glucosamine derivatives for cancer imaging

L. Carroll, Timothy H. Witney, E.O. Aboagye

Imaging Chemistry & Biology

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

The radiosynthesis of glucosamine and similar analogues would be of great interest due to their role in the biochemical synthesis of glycosylated proteins and lipids. This biochemistry can be exploited for visualisation of cancer cells via molecular imaging. This report details the synthesis of a number of 18F-labelled glucosamine derivatives and evaluation of their tumour uptake and normal tissue distribution in vivo in a mouse model of cancer by positron emission tomography (PET) imaging. © 2013 The Royal Society of Chemistry.

Original language	English
Pages (from-to)	653-656
Number of pages	4
Journal	MedChemComm
Volume	4
Issue number	4
DOIs	https://doi.org/10.1039/c3md00023k
Publication status	Published - 5 Feb 2013

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1039/c3md00023k

https://www.scopus.com/inward/record.uri?eid=2-s2.0-84876697732&doi=10.1039%2fc3md00023k&partnerID=40&md5=d2a3e4097ad6ba24a4b2a178836bc29a

Cite this

@article{6c9f329dde4c4566903914071e5e17f2,

title = "Design and synthesis of novel 18F-radiolabelled glucosamine derivatives for cancer imaging",

abstract = "The radiosynthesis of glucosamine and similar analogues would be of great interest due to their role in the biochemical synthesis of glycosylated proteins and lipids. This biochemistry can be exploited for visualisation of cancer cells via molecular imaging. This report details the synthesis of a number of 18F-labelled glucosamine derivatives and evaluation of their tumour uptake and normal tissue distribution in vivo in a mouse model of cancer by positron emission tomography (PET) imaging. {\textcopyright} 2013 The Royal Society of Chemistry.",

author = "L. Carroll and Witney, {Timothy H.} and E.O. Aboagye",

year = "2013",

month = feb,

day = "5",

doi = "10.1039/c3md00023k",

language = "English",

volume = "4",

pages = "653--656",

journal = "MedChemComm",

issn = "2040-2503",

publisher = "Royal Society of Chemistry",

number = "4",

}

TY - JOUR

T1 - Design and synthesis of novel 18F-radiolabelled glucosamine derivatives for cancer imaging

AU - Carroll, L.

AU - Witney, Timothy H.

AU - Aboagye, E.O.

PY - 2013/2/5

Y1 - 2013/2/5

N2 - The radiosynthesis of glucosamine and similar analogues would be of great interest due to their role in the biochemical synthesis of glycosylated proteins and lipids. This biochemistry can be exploited for visualisation of cancer cells via molecular imaging. This report details the synthesis of a number of 18F-labelled glucosamine derivatives and evaluation of their tumour uptake and normal tissue distribution in vivo in a mouse model of cancer by positron emission tomography (PET) imaging. © 2013 The Royal Society of Chemistry.

AB - The radiosynthesis of glucosamine and similar analogues would be of great interest due to their role in the biochemical synthesis of glycosylated proteins and lipids. This biochemistry can be exploited for visualisation of cancer cells via molecular imaging. This report details the synthesis of a number of 18F-labelled glucosamine derivatives and evaluation of their tumour uptake and normal tissue distribution in vivo in a mouse model of cancer by positron emission tomography (PET) imaging. © 2013 The Royal Society of Chemistry.

U2 - 10.1039/c3md00023k

DO - 10.1039/c3md00023k

M3 - Article

SN - 2040-2503

VL - 4

SP - 653

EP - 656

JO - MedChemComm

JF - MedChemComm

IS - 4

ER -

Design and synthesis of novel 18F-radiolabelled glucosamine derivatives for cancer imaging

Abstract

UN SDGs

Access to Document

Fingerprint

Cite this