King's College London

Research portal

Design, Synthesis and Discovery of N,N’-Carbazoyl-aryl-urea Inhibitors of Zika NS5 Methyltransferase and Virus Replication

Research output: Contribution to journalArticlepeer-review

Original languageEnglish
Pages (from-to)385-390
Number of pages6
Issue number4
Accepted/In press5 Dec 2019
Published17 Feb 2020


  • Final draft_0411

    Final_draft_0411.docx, 22 MB, application/vnd.openxmlformats-officedocument.wordprocessingml.document

    Uploaded date:06 Dec 2019

    Version:Accepted author manuscript

King's Authors


The recent outbreaks of Zika virus (ZIKV) infection worldwide make the discovery of novel antivirals against flaviviruses a research priority. This work describes the identification of novel inhibitors of ZIKV through a structure-based virtual screening approach using the ZIKV NS5-MTase. A novel series of molecules with a carbazoyl-aryl-urea structure has been discovered and a library of analogues has been synthesized. The new compounds inhibit ZIKV MTase with IC 50 between 23–48 μM. In addition, carbazoyl-aryl-ureas also proved to inhibit ZIKV replication activity at micromolar concentration.

Download statistics

No data available

View graph of relations

© 2020 King's College London | Strand | London WC2R 2LS | England | United Kingdom | Tel +44 (0)20 7836 5454