Detection of metabolites in the white matter of frontal lobes and hippocampus with proton in first-episode treatment-naive schizophrenia patients

TY - JOUR

T1 - Detection of metabolites in the white matter of frontal lobes and hippocampus with proton in first-episode treatment-naive schizophrenia patients

AU - He, Zong-Ling

AU - Deng, Wei

AU - Li, Ming-Li

AU - Chen, Zhuang-Fei

AU - Collier, David A.

AU - Ma, Xiaohong

AU - Li, Tao

PY - 2012/5

Y1 - 2012/5

N2 - Aim: This study aimed to investigate the changes of the metabolites in the white matter of frontal lobes and hippocampus in schizophrenia by using proton magnetic resonance spectroscopy (1H-MRS).  Methods: Sixty-three first-episode treatment-naive schizophrenia (FES) patients and 63 age-, gender-and education level-matched healthy controls were recruited. The relative levels of metabolites including N-acetylaspartate (NAA), cholinecontaining compounds (Cho) creatine plus phosphocreatine, (Cr) and myo-inositol (MI) were detected with 1H-MRS, and the laterality index (Li) was calculated. The severity of symptoms was assessed using the Positive and Negative Syndrome Scale.  Results: Compared with controls, FES patients did not show significant differences in all metabolites. The severity of positive symptoms was negatively correlated with the NAA/ Cho in the white matter of the left frontal lobe and positively correlated with the Cho/ Cr in the right white matter of frontal lobes. A negative correlation was observed between the severity of negative symptoms and the NAA/ Cr in the white matter of bilateral frontal lobes. No difference was shown in the Li of metabolites between FES patients and controls.  Conclusions: The metabolites such as NAA, Cho and MI in white matter of frontal lobes and hippocampus were not significantly altered in FES patients. The lower axonal integrity/ number (NAA concentration) may be associated with more severe negative symptoms, and dysmetabolism in process of myelination in the white matter of frontal lobes associated with more severe positive symptoms.

AB - Aim: This study aimed to investigate the changes of the metabolites in the white matter of frontal lobes and hippocampus in schizophrenia by using proton magnetic resonance spectroscopy (1H-MRS).  Methods: Sixty-three first-episode treatment-naive schizophrenia (FES) patients and 63 age-, gender-and education level-matched healthy controls were recruited. The relative levels of metabolites including N-acetylaspartate (NAA), cholinecontaining compounds (Cho) creatine plus phosphocreatine, (Cr) and myo-inositol (MI) were detected with 1H-MRS, and the laterality index (Li) was calculated. The severity of symptoms was assessed using the Positive and Negative Syndrome Scale.  Results: Compared with controls, FES patients did not show significant differences in all metabolites. The severity of positive symptoms was negatively correlated with the NAA/ Cho in the white matter of the left frontal lobe and positively correlated with the Cho/ Cr in the right white matter of frontal lobes. A negative correlation was observed between the severity of negative symptoms and the NAA/ Cr in the white matter of bilateral frontal lobes. No difference was shown in the Li of metabolites between FES patients and controls.  Conclusions: The metabolites such as NAA, Cho and MI in white matter of frontal lobes and hippocampus were not significantly altered in FES patients. The lower axonal integrity/ number (NAA concentration) may be associated with more severe negative symptoms, and dysmetabolism in process of myelination in the white matter of frontal lobes associated with more severe positive symptoms.

U2 - 10.1111/j.1751-7893.2011.00291.x

DO - 10.1111/j.1751-7893.2011.00291.x

M3 - Article

SN - 1751-7885

VL - 6

SP - 166

EP - 175

JO - Early Intervention in Psychiatry

JF - Early Intervention in Psychiatry

IS - 2

ER -