Determinants of physical function, as measured using PROMIS PF-10a, in patients with rheumatoid arthritis: results from the international COVID-19 Vaccination in Autoimmune Diseases (COVAD) study

TY - JOUR

T1 - Determinants of physical function, as measured using PROMIS PF-10a, in patients with rheumatoid arthritis

T2 - results from the international COVID-19 Vaccination in Autoimmune Diseases (COVAD) study

AU - COVAD Study Group

AU - Ali, Saadia Sasha

AU - Demetriou, Christiana

AU - Parodis, Ioannis

AU - Tan, Ai Lyn

AU - Edgar Gracia-Ramos, Abraham

AU - Joshi, Mrudula

AU - Caballero-Uribe, Carlo V

AU - Saha, Sreoshy

AU - Lilleker, James B

AU - Nune, Arvind

AU - Pauling, John D

AU - Wincup, Chris

AU - Jagtap, Kshitij

AU - Dey, Dzifa

AU - Milchert, Marcin

AU - Distler, Oliver

AU - Chinoy, Hector

AU - Agarwal, Vikas

AU - Gupta, Latika

AU - Nikiphorou, Elena

N1 - © The Author(s) 2024. Published by Oxford University Press on behalf of the British Society for Rheumatology.

PY - 2025

Y1 - 2025

N2 - OBJECTIVES: Physical function in RA is largely influenced by multiple clinical factors, however, there is a growing body of evidence that psychological state and other comorbidities also play an essential role. Using data obtained in the COVID-19 Vaccination in Autoimmune Diseases study, an international self-reported e-survey, we aimed to explore the predictive ability of sociodemographic and clinical variables on Patient-Reported Outcomes Measurement Information System Physical Function Short Form 10a (PROMIS PF-10a) in RA and to investigate variation in disease activity and functional outcomes based on country-level socio-economic parameters.METHODS: Patient demographics, disease characteristics including current symptom status, functional status and treatment variables, as well as income level of the country of residence, were extracted from survey responses. PROMIS PF-10a scores were compared across country income levels. The influence of extracted variables on reversed PROMIS PF-10a scores were investigated using negative binomial univariable- and multivariable regression.RESULTS: A total of 1342 RA patients were included in this analysis. In the optimised parsimonious predictive model for reversed PROMIS PF-10a, older age, female gender, disease duration, fatigue and pain levels were independently associated with worse physical function, whereas Asian ethnicity, higher overall physical health ratings, ability to carry out everyday activities and residing in a country with an upper-middle or high-income level were independently associated with better physical function.CONCLUSION: Our study highlights that clinical factors remain strong predictors of physical function in RA, irrespective of individual and country-level socio-economic differences. Interestingly, high country-level income was associated with better physical function, irrespective of individual sociodemographic and clinical factors.

AB - OBJECTIVES: Physical function in RA is largely influenced by multiple clinical factors, however, there is a growing body of evidence that psychological state and other comorbidities also play an essential role. Using data obtained in the COVID-19 Vaccination in Autoimmune Diseases study, an international self-reported e-survey, we aimed to explore the predictive ability of sociodemographic and clinical variables on Patient-Reported Outcomes Measurement Information System Physical Function Short Form 10a (PROMIS PF-10a) in RA and to investigate variation in disease activity and functional outcomes based on country-level socio-economic parameters.METHODS: Patient demographics, disease characteristics including current symptom status, functional status and treatment variables, as well as income level of the country of residence, were extracted from survey responses. PROMIS PF-10a scores were compared across country income levels. The influence of extracted variables on reversed PROMIS PF-10a scores were investigated using negative binomial univariable- and multivariable regression.RESULTS: A total of 1342 RA patients were included in this analysis. In the optimised parsimonious predictive model for reversed PROMIS PF-10a, older age, female gender, disease duration, fatigue and pain levels were independently associated with worse physical function, whereas Asian ethnicity, higher overall physical health ratings, ability to carry out everyday activities and residing in a country with an upper-middle or high-income level were independently associated with better physical function.CONCLUSION: Our study highlights that clinical factors remain strong predictors of physical function in RA, irrespective of individual and country-level socio-economic differences. Interestingly, high country-level income was associated with better physical function, irrespective of individual sociodemographic and clinical factors.

KW - country-level income

KW - COVAD

KW - e-survey

KW - patient-reported outcome measures

KW - physical function

KW - PROMIS

KW - rheumatoid arthritis

KW - sociodemographic factors

UR - http://www.scopus.com/inward/record.url?scp=85216842226&partnerID=8YFLogxK

U2 - 10.1093/rap/rkae154

DO - 10.1093/rap/rkae154

M3 - Article

C2 - 39846050

AN - SCOPUS:85216842226

SN - 2514-1775

VL - 9

SP - rkae154

JO - Rheumatology Advances in Practice

JF - Rheumatology Advances in Practice

IS - 1

M1 - rkae154

ER -