Determination of atrial myofibre orientation using structure tensor analysis for biophysical modelling

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Abstract

Myofibre orientation plays an important role in electrical activation patterns in the heart. Biophysical models of the whole atria, however, have not yet incorporated realistic myofibre architecture. In this study, we use structure tensor (ST) analysis to determine myofibre orientation from high resolution micro-computed tomography (micro-CT) images and investigate the role of different ST image processing parameters on the computed fibre orientation fields. We found that, although some parameter sets can lead to non-physiological over- or under-smooth fibre fields, a wide range of values produced atrial fibre orientations that are in good agreement with previous anatomical and histological studies. The computed fibre fields can be incorporated in realistic 3D electrophysiological simulations to study electrical propagation under physiological and pathological conditions in the entire atria.
Original languageEnglish
Title of host publicationFunctional Imaging and Modeling of the Heart
Subtitle of host publication7th International Conference, FIMH 2013, proceedings
EditorsSebastian Ourselin, Daniel Rueckert, Nicolas Smith
Place of PublicationBerlin
PublisherSpringer Berlin Heidelberg
Pages425-432
Number of pages8
ISBN (Print)9783642388989
DOIs
Publication statusPublished - 2013

Publication series

NameLecture Notes in Computer Science
PublisherSpringer Berlin Heidelberg
Volume7945
ISSN (Print)0302-9743

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