Determining signalling nodes for apoptosis by a genetic high-throughput screen

Bevan Lin; Derek Huntley; Ghada Abuali; Sarah R Langley; George Sindelar; Enrico Petretto; Sarah Butcher; Stefan Grimm

doi:10.1371/journal.pone.0025023

Determining signalling nodes for apoptosis by a genetic high-throughput screen

Bevan Lin, Derek Huntley, Ghada Abuali, Sarah R Langley, George Sindelar, Enrico Petretto, Sarah Butcher, Stefan Grimm

Cardiovascular Sciences

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

With the ever-increasing information emerging from the various sequencing and gene annotation projects, there is an urgent need to elucidate the cellular functions of the newly discovered genes. The genetically regulated cell suicide of apoptosis is especially suitable for such endeavours as it is governed by a vast number of factors.

Original language	English
Pages (from-to)	e25023
Journal	PLoS ONE
Volume	6
Issue number	9
DOIs	https://doi.org/10.1371/journal.pone.0025023
Publication status	Published - 2011

Keywords

Animals
Apoptosis
Computational Biology
DNA, Complementary
Enzyme-Linked Immunosorbent Assay
Gene Expression Profiling
Gene Expression Regulation, Neoplastic
Genomics
Green Fluorescent Proteins
HEK293 Cells
Humans
Mice
Models, Genetic
Oligonucleotide Array Sequence Analysis
Robotics
Signal Transduction
Subcellular Fractions

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1371/journal.pone.0025023

Cite this

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T1 - Determining signalling nodes for apoptosis by a genetic high-throughput screen

AU - Lin, Bevan

AU - Huntley, Derek

AU - Abuali, Ghada

AU - Langley, Sarah R

AU - Sindelar, George

AU - Petretto, Enrico

AU - Butcher, Sarah

AU - Grimm, Stefan

PY - 2011

Y1 - 2011

N2 - With the ever-increasing information emerging from the various sequencing and gene annotation projects, there is an urgent need to elucidate the cellular functions of the newly discovered genes. The genetically regulated cell suicide of apoptosis is especially suitable for such endeavours as it is governed by a vast number of factors.

AB - With the ever-increasing information emerging from the various sequencing and gene annotation projects, there is an urgent need to elucidate the cellular functions of the newly discovered genes. The genetically regulated cell suicide of apoptosis is especially suitable for such endeavours as it is governed by a vast number of factors.

KW - Animals

KW - Apoptosis

KW - Computational Biology

KW - DNA, Complementary

KW - Enzyme-Linked Immunosorbent Assay

KW - Gene Expression Profiling

KW - Gene Expression Regulation, Neoplastic

KW - Genomics

KW - Green Fluorescent Proteins

KW - HEK293 Cells

KW - Humans

KW - Mice

KW - Models, Genetic

KW - Oligonucleotide Array Sequence Analysis

KW - Robotics

KW - Signal Transduction

KW - Subcellular Fractions

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DO - 10.1371/journal.pone.0025023

M3 - Article

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SN - 1932-6203

VL - 6

SP - e25023

JO - PLoS ONE

JF - PLoS ONE

IS - 9

ER -

Determining signalling nodes for apoptosis by a genetic high-throughput screen

Abstract

Keywords

UN SDGs

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