Deuteros: software for rapid analysis and visualization of data from differential hydrogen deuterium exchange-mass spectrometry

Andy Man Chung Lau; Zainab Ahdash; Chloe Martens; Argyris Politis

Deuteros: software for rapid analysis and visualization of data from differential hydrogen deuterium exchange-mass spectrometry

Andy Man Chung Lau, Zainab Ahdash, Chloe Martens, Argyris Politis

Chemistry

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Abstract

Hydrogen deuterium exchange-mass spectrometry (HDX-MS) has emerged as a powerful technique for interrogating the conformational dynamics of proteins and their complexes. Currently, analysis of HDX-MS data remains a laborious procedure, mainly due to the lack of streamlined software to process the large datasets. We present Deuteros which is a standalone software designed to be coupled with Waters DynamX HDX data analysis software, allowing the rapid analysis and visualization of data from differential HDX-MS.

Original language	English
Journal	BIOINFORMATICS
Publication status	Accepted/In press - 29 Dec 2018

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title = "Deuteros: software for rapid analysis and visualization of data from differential hydrogen deuterium exchange-mass spectrometry",

abstract = "Hydrogen deuterium exchange-mass spectrometry (HDX-MS) has emerged as a powerful technique for interrogating the conformational dynamics of proteins and their complexes. Currently, analysis of HDX-MS data remains a laborious procedure, mainly due to the lack of streamlined software to process the large datasets. We present Deuteros which is a standalone software designed to be coupled with Waters DynamX HDX data analysis software, allowing the rapid analysis and visualization of data from differential HDX-MS. ",

author = "Lau, {Andy Man Chung} and Zainab Ahdash and Chloe Martens and Argyris Politis",

year = "2018",

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T1 - Deuteros: software for rapid analysis and visualization of data from differential hydrogen deuterium exchange-mass spectrometry

AU - Lau, Andy Man Chung

AU - Ahdash, Zainab

AU - Martens, Chloe

AU - Politis, Argyris

PY - 2018/12/29

Y1 - 2018/12/29

N2 - Hydrogen deuterium exchange-mass spectrometry (HDX-MS) has emerged as a powerful technique for interrogating the conformational dynamics of proteins and their complexes. Currently, analysis of HDX-MS data remains a laborious procedure, mainly due to the lack of streamlined software to process the large datasets. We present Deuteros which is a standalone software designed to be coupled with Waters DynamX HDX data analysis software, allowing the rapid analysis and visualization of data from differential HDX-MS.

AB - Hydrogen deuterium exchange-mass spectrometry (HDX-MS) has emerged as a powerful technique for interrogating the conformational dynamics of proteins and their complexes. Currently, analysis of HDX-MS data remains a laborious procedure, mainly due to the lack of streamlined software to process the large datasets. We present Deuteros which is a standalone software designed to be coupled with Waters DynamX HDX data analysis software, allowing the rapid analysis and visualization of data from differential HDX-MS.

M3 - Article

SN - 1367-4803

JO - BIOINFORMATICS

JF - BIOINFORMATICS

ER -

Deuteros: software for rapid analysis and visualization of data from differential hydrogen deuterium exchange-mass spectrometry

Abstract

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