Developing the future of clinical radiopharmacy: Optimising on-chip gallium-68 radiolabelling for pet imaging

Vincent Nail, Mark D. Tarn, Ping He, Nicole Pamme, Stephen J. Archibald*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference paperpeer-review

Abstract

Positron emission tomography (PET) imaging is a growing area with major interest in radiometal labelling and dose-on-demand supply. However, current production methods do not match effectively with these requirements. Microreactor technology is a promising candidate as a future standard radiosynthesis tool. The fluid transport is commonly achieved using syringe pump, but it cannot handle different processes alongside. Herein, we describe an alternative fluid transport mechanism for gallium-68 radiolabelling via peristaltic pump. The optimisation of this reaction yielded a two-fold decrease in the required quantity of chelator after 4 min of reaction at room temperature.

Original languageEnglish
Title of host publicationMicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PublisherChemical and Biological Microsystems Society
Pages715-716
Number of pages2
ISBN (Electronic)9781733419017
Publication statusPublished - 2020
Event24th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2020 - Virtual, Online
Duration: 4 Oct 20209 Oct 2020

Publication series

NameMicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences

Conference

Conference24th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2020
CityVirtual, Online
Period4/10/20209/10/2020

Keywords

  • Molecular imaging
  • PET
  • Positron emission tomography
  • Radiolabelling
  • Synthetic chemistry

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