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Development and function of human dendritic cells in humanized mice models

Research output: Contribution to journalReview article

Original languageEnglish
Pages (from-to)151-161
Number of pages11
JournalMolecular Immunology
Volume125
DOIs
PublishedSep 2020

King's Authors

Abstract

Dendritic cells (DCs) are sentinel cells of the immune system arising from hematopoietic stem cells. DCs play a key role in the regulation of both adaptive and innate lymphocyte responses. As such, experimental models enabling a thorough analysis of human DCs development and function are needed. Humanized mice models (termed collectively as HIS mice, or human immune system mice models) provide unique opportunities to model human hematopoiesis and tackle the function of human immune cell types in vivo. Here, we review experimental approaches enabling to recapitulate the ontogeny of DC subsets in HIS mice and discuss studies addressing the biology of human DC subsets implementing HIS mice models.

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