TY - JOUR
T1 - Development and predictors of bipolar disorder in children and adolescents with depressive disorders: a systematic review, meta-analysis, and meta-regression
AU - Salazar de Pablo, Gonzalo
AU - Perez-Rodriguez, Violeta
AU - de Otazu Olivares, Javier
AU - Camacho-Rubio, Javier
AU - Sharma, Aditya Narain
AU - Catalan, Ana
AU - Breedvelt, Josefien
AU - Aymerich, Claudia
AU - Pop, Mihai
AU - Moreno, Carmen
AU - Kelleher , Ian
AU - Anderson, Jane
AU - Fusar-Poli, Paolo
AU - Correll, Christoph U
AU - Young, Allan
N1 - Publisher Copyright:
© The Author(s), 2025.
PY - 2025/1/8
Y1 - 2025/1/8
N2 - Background: Estimating the risk of developing bipolar disorder (BD) in children and adolescents (C&A) with depressive disorders and identifying predictors for developing BD is important to optimize prevention and early intervention efforts. This systematic review and meta-analysis aimed to quantitatively examine this risk of developing BD from depressive disorders and identify factors which moderate this development. Methods: In this systematic review and meta-analysis (PROSPERO:CRD42023431301), PubMed and Web-of-Science databases were searched for longitudinal studies reporting the percentage of C&A with ICD/DSM-defined depressive disorders who developed BD during follow-up. Data extraction, random-effects meta-analysis, between-study heterogeneity analysis, quality assessment, sub-group analyses and meta-regressions were conducted. Results: 39 studies were included, including 72,371 individuals (mean age=13.9 years, 57.1% females). 14.7% of C&A with a depressive disorder developed BD after 20.4–288 months: 9.5% developed BD-I (95%CI=4.7–18.1); 7.7% developed BD-II (95%CI=3.2–17.3%). 19.8% (95%CI=9.9–35.6%) of C&A admitted into the hospital with a depressive disorder developed BD. Studies using the DSM (21.6%, 95%CI=20.2-23.1%) and studies evaluating C&A with a major depressive disorder only (19.8%, 95%CI=16.8-23.1%) found higher rates of development of BD. Younger age at baseline, a history of hospitalization and recruitment from specialized clinics were associated with an increased risk of developing BD at follow-up. Quality of included studies was good in 76.9% studies. Conclusions: There is a substantial risk of developing BD in C&A with depressive disorders. This is particularly the case for C&A with MDD, DSM-diagnosed depressive disorders, and C&A admitted into hospital. Research exploring additional predictors and preventive interventions is crucial.
AB - Background: Estimating the risk of developing bipolar disorder (BD) in children and adolescents (C&A) with depressive disorders and identifying predictors for developing BD is important to optimize prevention and early intervention efforts. This systematic review and meta-analysis aimed to quantitatively examine this risk of developing BD from depressive disorders and identify factors which moderate this development. Methods: In this systematic review and meta-analysis (PROSPERO:CRD42023431301), PubMed and Web-of-Science databases were searched for longitudinal studies reporting the percentage of C&A with ICD/DSM-defined depressive disorders who developed BD during follow-up. Data extraction, random-effects meta-analysis, between-study heterogeneity analysis, quality assessment, sub-group analyses and meta-regressions were conducted. Results: 39 studies were included, including 72,371 individuals (mean age=13.9 years, 57.1% females). 14.7% of C&A with a depressive disorder developed BD after 20.4–288 months: 9.5% developed BD-I (95%CI=4.7–18.1); 7.7% developed BD-II (95%CI=3.2–17.3%). 19.8% (95%CI=9.9–35.6%) of C&A admitted into the hospital with a depressive disorder developed BD. Studies using the DSM (21.6%, 95%CI=20.2-23.1%) and studies evaluating C&A with a major depressive disorder only (19.8%, 95%CI=16.8-23.1%) found higher rates of development of BD. Younger age at baseline, a history of hospitalization and recruitment from specialized clinics were associated with an increased risk of developing BD at follow-up. Quality of included studies was good in 76.9% studies. Conclusions: There is a substantial risk of developing BD in C&A with depressive disorders. This is particularly the case for C&A with MDD, DSM-diagnosed depressive disorders, and C&A admitted into hospital. Research exploring additional predictors and preventive interventions is crucial.
UR - http://www.scopus.com/inward/record.url?scp=85214929513&partnerID=8YFLogxK
U2 - 10.1192/j.eurpsy.2024.1814
DO - 10.1192/j.eurpsy.2024.1814
M3 - Review article
SN - 0924-9338
JO - European Psychiatry
JF - European Psychiatry
ER -