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Development of coumarin-thiosemicarbazone hybrids as aldose reductase inhibitors: Biological assays, molecular docking, simulation studies and ADME evaluation

Research output: Contribution to journalArticlepeer-review

Aqeel Imran, Muhammad Tariq Shehzad, Taha al Adhami, Khondaker Miraz Rahman, Dilawar Hussain, Rima D. Alharthy, Zahid Shafiq, Jamshed Iqbal

Original languageEnglish
Article number105164
JournalBIOORGANIC CHEMISTRY
Volume115
DOIs
PublishedOct 2021

Bibliographical note

Funding Information: A. Imran is thankful to Higher Education commission, Pakistan for awarding scholarship under International Research Support Initiative Program (IRSIP) through award no. 1-8/HEC/HRD/2019/8892. Publisher Copyright: © 2021 Elsevier Inc. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

King's Authors

Abstract

The over expression of aldose reductase (ALR2) in the state of hyperglycemia causes the conversion of glucose into sorbitol and initiates polyol pathway. Accumulation of sorbitol in insulin insensitive tissue like peripheral nerves, glomerulus and eyes, induces diabetic complications like neuropathy, nephropathy and retinopathy. For the treatment of diabetic complications, the inhibition of aldose reductase (ALR2) is a promising approach. A series of coumarin-based thiosemicarbazone derivatives was synthesized as potential inhibitor of aldose reductase. Compound N-(2-fluorophenyl)-2-(1-(2-oxo-2H-chromen-3-yl)ethylidene)hydrazinecarbiothioamide (3n) was found to be the most promising inhibitor of ALR2 with an IC50 in micromolar range (2.07 µM) and high selectivity, relative to ALR1. The crystal structure of ALR2 complexed with 3n explored the types of interaction pattern which further demonstrated its high affinity. Compound 3n has excellent lead-likeness, underlined by its physicochemical parameters, and can be considered as a likely prospect for further structural optimization to get a drugable molecule.

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