Development of Non-Contact Device Based on Optical Fibre Technology for Detecting Respiration of Small Animal in Imaging Instruments

TY - GEN

T1 - Development of Non-Contact Device Based on Optical Fibre Technology for Detecting Respiration of Small Animal in Imaging Instruments

AU - Prompalit, Sakunrat

AU - Fruhwirth, Gilbert

AU - Rhode, Kawal

AU - Noh, Yohan

PY - 2018/12/26

Y1 - 2018/12/26

N2 - Pre-processed images obtained from preclinical studies contain non-desirable artefacts due to the presence of pressure sensing parts of a respiration detector. Nonetheless, respiration monitoring is inevitable in imaging procedures, as it provides realtime information about changes in animals' wellbeing. Several imaging techniques have been adopted into developing alternative devices for measuring heart and respiration rates. One of the studies mention the use of optical fibres, by attaching fibres to a modified chamber structure. The fibres are still closely attached to a mouse and possibly cause artefacts. A pair of optical fibres are placed above the mouse, are connected to a fibre optic sensor which consists of an LED and a photodiode, and therefore can detect movement of abdominal walls and thus the respiration (Fig. 1(a)). In this paper, we propose to introduce an easy-to-integrate design of a non-contact respiration detector based on this principle. The concept of the initial design and experiments were constructed from mouse and Nano PET/CT (Fig. 1(b)), since mice are the focus of current preclinical research. A set of experiments were conducted to find sets of fibre arrangements that produce large voltage variations of the fibre optic sensor with respect to small movement changes regarding different fur colours. The selected fibre positions were later tested in a mouse simulation model to accredit acquired results and to possibly use on a real device. The toy filling in a model mouse was replaced with partially inflating balloon and mouse's breathing behaviour was controlled by using a pumping mechanism.

AB - Pre-processed images obtained from preclinical studies contain non-desirable artefacts due to the presence of pressure sensing parts of a respiration detector. Nonetheless, respiration monitoring is inevitable in imaging procedures, as it provides realtime information about changes in animals' wellbeing. Several imaging techniques have been adopted into developing alternative devices for measuring heart and respiration rates. One of the studies mention the use of optical fibres, by attaching fibres to a modified chamber structure. The fibres are still closely attached to a mouse and possibly cause artefacts. A pair of optical fibres are placed above the mouse, are connected to a fibre optic sensor which consists of an LED and a photodiode, and therefore can detect movement of abdominal walls and thus the respiration (Fig. 1(a)). In this paper, we propose to introduce an easy-to-integrate design of a non-contact respiration detector based on this principle. The concept of the initial design and experiments were constructed from mouse and Nano PET/CT (Fig. 1(b)), since mice are the focus of current preclinical research. A set of experiments were conducted to find sets of fibre arrangements that produce large voltage variations of the fibre optic sensor with respect to small movement changes regarding different fur colours. The selected fibre positions were later tested in a mouse simulation model to accredit acquired results and to possibly use on a real device. The toy filling in a model mouse was replaced with partially inflating balloon and mouse's breathing behaviour was controlled by using a pumping mechanism.

UR - http://www.scopus.com/inward/record.url?scp=85060851886&partnerID=8YFLogxK

U2 - 10.1109/ICSENS.2018.8589570

DO - 10.1109/ICSENS.2018.8589570

M3 - Conference contribution

AN - SCOPUS:85060851886

VL - 2018-October

BT - 2018 IEEE SENSORS, SENSORS 2018 - Conference Proceedings

PB - Institute of Electrical and Electronics Engineers Inc.

T2 - 17th IEEE SENSORS Conference, SENSORS 2018

Y2 - 28 October 2018 through 31 October 2018

ER -