TY - JOUR
T1 - Development of radiodetection systems towards miniaturised quality control of PET and SPECT radiopharmaceuticals
AU - Taggart, Matthew P.
AU - Tarn, Mark D.
AU - Esfahani, Mohammad M.N.
AU - Schofield, Daniel M.
AU - Brown, Nathaniel J.
AU - Archibald, Stephen J.
AU - Deakin, Tom
AU - Pamme, Nicole
AU - Thompson, Lee F.
N1 - Publisher Copyright:
© 2016 The Royal Society of Chemistry.
PY - 2016
Y1 - 2016
N2 - The ability to detect radiation in microfluidic devices is important for the on-chip analysis of radiopharmaceuticals, but previously reported systems have largely suffered from various limitations including cost, complexity of fabrication, and insufficient sensitivity and/or speed. Here, we present the use of sensitive, low cost, small-sized, commercially available silicon photomultipliers (SiPMs) for the detection of radioactivity inside microfluidic channels fabricated from a range of conventional microfluidic chip substrates. We demonstrate the effects of chip material and thickness on the detection of the positron-emitting isotope, [18F]fluoride, and find that, while the SiPMs are light sensors, they are able to detect radiation even through opaque chip materials via direct positron and gamma (γ) ray interaction. Finally, we employed the SiPM platform for analysis of the PET (positron emission tomography) radiotracers 2-[18F]fluoro-2-deoxy-d-glucose ([18F]FDG) and [68Ga]gallium-citrate, and highlight the ability to detect the γ ray emitting SPECT (single photon emission computed tomography) radiotracer, [99mTc]pertechnetate.
AB - The ability to detect radiation in microfluidic devices is important for the on-chip analysis of radiopharmaceuticals, but previously reported systems have largely suffered from various limitations including cost, complexity of fabrication, and insufficient sensitivity and/or speed. Here, we present the use of sensitive, low cost, small-sized, commercially available silicon photomultipliers (SiPMs) for the detection of radioactivity inside microfluidic channels fabricated from a range of conventional microfluidic chip substrates. We demonstrate the effects of chip material and thickness on the detection of the positron-emitting isotope, [18F]fluoride, and find that, while the SiPMs are light sensors, they are able to detect radiation even through opaque chip materials via direct positron and gamma (γ) ray interaction. Finally, we employed the SiPM platform for analysis of the PET (positron emission tomography) radiotracers 2-[18F]fluoro-2-deoxy-d-glucose ([18F]FDG) and [68Ga]gallium-citrate, and highlight the ability to detect the γ ray emitting SPECT (single photon emission computed tomography) radiotracer, [99mTc]pertechnetate.
UR - http://www.scopus.com/inward/record.url?scp=84966738910&partnerID=8YFLogxK
U2 - 10.1039/c6lc00099a
DO - 10.1039/c6lc00099a
M3 - Article
C2 - 27044712
AN - SCOPUS:84966738910
SN - 1473-0197
VL - 16
SP - 1605
EP - 1616
JO - Lab on a chip
JF - Lab on a chip
IS - 9
ER -