Development of the cerebellum: simple steps to make a ‘little brain'

Research output: Contribution to journalLiterature reviewpeer-review

160 Citations (Scopus)

Abstract

The cerebellum is a pre-eminent model for the study of neurogenesis and circuit assembly. Increasing interest in the cerebellum as a participant in higher cognitive processes and as a locus for a range of disorders and diseases make this simple yet elusive structure an important model in a number of fields. In recent years, our understanding of some of the more familiar aspects of cerebellar growth, such as its territorial allocation and the origin of its various cell types, has undergone major recalibration. Furthermore, owing to its stereotyped circuitry across a range of species, insights from a variety of species have contributed to an increasingly rich picture of how this system develops. Here, we review these recent advances and explore three distinct aspects of cerebellar development – allocation of the cerebellar anlage, the significance of transit amplification and the generation of neuronal diversity – each defined by distinct regulatory mechanisms and each with special significance for health and disease.
Original languageEnglish
Pages (from-to)4031-4041
Number of pages11
JournalDevelopment (Cambridge): for advances in developmental biology and stem cells
Volume141
Issue number21
DOIs
Publication statusPublished - Nov 2014

Fingerprint

Dive into the research topics of 'Development of the cerebellum: simple steps to make a ‘little brain''. Together they form a unique fingerprint.

Cite this