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Developmental programming mediated by complementary roles of imprinted Grb10 in mother and pup

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Developmental programming mediated by complementary roles of imprinted Grb10 in mother and pup. / Cowley, Michael; Garfield, Alastair S; Madon-Simon, Marta; Charalambous, Marika; Clarkson, Richard W; Smalley, Matthew J; Kendrick, Howard; Isles, Anthony R; Parry, Aled J; Carney, Sara; Oakey, Rebecca J; Heisler, Lora K; Moorwood, Kim; Wolf, Jason B; Ward, Andrew.

In: PL o S Biology, Vol. 12, No. 2, e1001799, 25.02.2014.

Research output: Contribution to journalArticle

Harvard

Cowley, M, Garfield, AS, Madon-Simon, M, Charalambous, M, Clarkson, RW, Smalley, MJ, Kendrick, H, Isles, AR, Parry, AJ, Carney, S, Oakey, RJ, Heisler, LK, Moorwood, K, Wolf, JB & Ward, A 2014, 'Developmental programming mediated by complementary roles of imprinted Grb10 in mother and pup', PL o S Biology, vol. 12, no. 2, e1001799. https://doi.org/10.1371/journal.pbio.1001799

APA

Cowley, M., Garfield, A. S., Madon-Simon, M., Charalambous, M., Clarkson, R. W., Smalley, M. J., Kendrick, H., Isles, A. R., Parry, A. J., Carney, S., Oakey, R. J., Heisler, L. K., Moorwood, K., Wolf, J. B., & Ward, A. (2014). Developmental programming mediated by complementary roles of imprinted Grb10 in mother and pup. PL o S Biology, 12(2), [e1001799]. https://doi.org/10.1371/journal.pbio.1001799

Vancouver

Cowley M, Garfield AS, Madon-Simon M, Charalambous M, Clarkson RW, Smalley MJ et al. Developmental programming mediated by complementary roles of imprinted Grb10 in mother and pup. PL o S Biology. 2014 Feb 25;12(2). e1001799. https://doi.org/10.1371/journal.pbio.1001799

Author

Cowley, Michael ; Garfield, Alastair S ; Madon-Simon, Marta ; Charalambous, Marika ; Clarkson, Richard W ; Smalley, Matthew J ; Kendrick, Howard ; Isles, Anthony R ; Parry, Aled J ; Carney, Sara ; Oakey, Rebecca J ; Heisler, Lora K ; Moorwood, Kim ; Wolf, Jason B ; Ward, Andrew. / Developmental programming mediated by complementary roles of imprinted Grb10 in mother and pup. In: PL o S Biology. 2014 ; Vol. 12, No. 2.

Bibtex Download

@article{074a0814b0364f32be5b1df1c9803f18,
title = "Developmental programming mediated by complementary roles of imprinted Grb10 in mother and pup",
abstract = "Developmental programming links growth in early life with health status in adulthood. Although environmental factors such as maternal diet can influence the growth and adult health status of offspring, the genetic influences on this process are poorly understood. Using the mouse as a model, we identify the imprinted gene Grb10 as a mediator of nutrient supply and demand in the postnatal period. The combined actions of Grb10 expressed in the mother, controlling supply, and Grb10 expressed in the offspring, controlling demand, jointly regulate offspring growth. Furthermore, Grb10 determines the proportions of lean and fat tissue during development, thereby influencing energy homeostasis in the adult. Most strikingly, we show that the development of normal lean/fat proportions depends on the combined effects of Grb10 expressed in the mother, which has the greater effect on offspring adiposity, and Grb10 expressed in the offspring, which influences lean mass. These distinct functions of Grb10 in mother and pup act complementarily, which is consistent with a coadaptation model of imprinting evolution, a model predicted but for which there is limited experimental evidence. In addition, our findings identify Grb10 as a key genetic component of developmental programming, and highlight the need for a better understanding of mother-offspring interactions at the genetic level in predicting adult disease risk. ",
keywords = "Animals, Body Size/genetics, Female, GRB10 Adaptor Protein/genetics, Gene Expression Regulation, Developmental, Genomic Imprinting, Karyopherins/physiology, Lactation/genetics, Mice, Mice, Knockout, Receptors, Cytoplasmic and Nuclear/physiology, STAT5 Transcription Factor/physiology",
author = "Michael Cowley and Garfield, {Alastair S} and Marta Madon-Simon and Marika Charalambous and Clarkson, {Richard W} and Smalley, {Matthew J} and Howard Kendrick and Isles, {Anthony R} and Parry, {Aled J} and Sara Carney and Oakey, {Rebecca J} and Heisler, {Lora K} and Kim Moorwood and Wolf, {Jason B} and Andrew Ward",
year = "2014",
month = feb,
day = "25",
doi = "10.1371/journal.pbio.1001799",
language = "English",
volume = "12",
journal = "PL o S Biology",
issn = "1544-9173",
number = "2",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Developmental programming mediated by complementary roles of imprinted Grb10 in mother and pup

AU - Cowley, Michael

AU - Garfield, Alastair S

AU - Madon-Simon, Marta

AU - Charalambous, Marika

AU - Clarkson, Richard W

AU - Smalley, Matthew J

AU - Kendrick, Howard

AU - Isles, Anthony R

AU - Parry, Aled J

AU - Carney, Sara

AU - Oakey, Rebecca J

AU - Heisler, Lora K

AU - Moorwood, Kim

AU - Wolf, Jason B

AU - Ward, Andrew

PY - 2014/2/25

Y1 - 2014/2/25

N2 - Developmental programming links growth in early life with health status in adulthood. Although environmental factors such as maternal diet can influence the growth and adult health status of offspring, the genetic influences on this process are poorly understood. Using the mouse as a model, we identify the imprinted gene Grb10 as a mediator of nutrient supply and demand in the postnatal period. The combined actions of Grb10 expressed in the mother, controlling supply, and Grb10 expressed in the offspring, controlling demand, jointly regulate offspring growth. Furthermore, Grb10 determines the proportions of lean and fat tissue during development, thereby influencing energy homeostasis in the adult. Most strikingly, we show that the development of normal lean/fat proportions depends on the combined effects of Grb10 expressed in the mother, which has the greater effect on offspring adiposity, and Grb10 expressed in the offspring, which influences lean mass. These distinct functions of Grb10 in mother and pup act complementarily, which is consistent with a coadaptation model of imprinting evolution, a model predicted but for which there is limited experimental evidence. In addition, our findings identify Grb10 as a key genetic component of developmental programming, and highlight the need for a better understanding of mother-offspring interactions at the genetic level in predicting adult disease risk.

AB - Developmental programming links growth in early life with health status in adulthood. Although environmental factors such as maternal diet can influence the growth and adult health status of offspring, the genetic influences on this process are poorly understood. Using the mouse as a model, we identify the imprinted gene Grb10 as a mediator of nutrient supply and demand in the postnatal period. The combined actions of Grb10 expressed in the mother, controlling supply, and Grb10 expressed in the offspring, controlling demand, jointly regulate offspring growth. Furthermore, Grb10 determines the proportions of lean and fat tissue during development, thereby influencing energy homeostasis in the adult. Most strikingly, we show that the development of normal lean/fat proportions depends on the combined effects of Grb10 expressed in the mother, which has the greater effect on offspring adiposity, and Grb10 expressed in the offspring, which influences lean mass. These distinct functions of Grb10 in mother and pup act complementarily, which is consistent with a coadaptation model of imprinting evolution, a model predicted but for which there is limited experimental evidence. In addition, our findings identify Grb10 as a key genetic component of developmental programming, and highlight the need for a better understanding of mother-offspring interactions at the genetic level in predicting adult disease risk.

KW - Animals

KW - Body Size/genetics

KW - Female

KW - GRB10 Adaptor Protein/genetics

KW - Gene Expression Regulation, Developmental

KW - Genomic Imprinting

KW - Karyopherins/physiology

KW - Lactation/genetics

KW - Mice

KW - Mice, Knockout

KW - Receptors, Cytoplasmic and Nuclear/physiology

KW - STAT5 Transcription Factor/physiology

U2 - 10.1371/journal.pbio.1001799

DO - 10.1371/journal.pbio.1001799

M3 - Article

C2 - 24586114

VL - 12

JO - PL o S Biology

JF - PL o S Biology

SN - 1544-9173

IS - 2

M1 - e1001799

ER -

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