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Developmentally dynamic genome: Evidence of genetic influences on increases and decreases in conduct problems from early childhood to adolescence

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Developmentally dynamic genome : Evidence of genetic influences on increases and decreases in conduct problems from early childhood to adolescence. / Pingault, Jean-Baptiste; Rijsdijk, Frühling; Zheng, Yao; Plomin, Robert; Viding, Essi.

In: Scientific Reports, Vol. 5, 10053, 06.05.2015.

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Harvard

Pingault, J-B, Rijsdijk, F, Zheng, Y, Plomin, R & Viding, E 2015, 'Developmentally dynamic genome: Evidence of genetic influences on increases and decreases in conduct problems from early childhood to adolescence', Scientific Reports, vol. 5, 10053. https://doi.org/10.1038/srep10053

APA

Pingault, J-B., Rijsdijk, F., Zheng, Y., Plomin, R., & Viding, E. (2015). Developmentally dynamic genome: Evidence of genetic influences on increases and decreases in conduct problems from early childhood to adolescence. Scientific Reports, 5, [10053]. https://doi.org/10.1038/srep10053

Vancouver

Pingault J-B, Rijsdijk F, Zheng Y, Plomin R, Viding E. Developmentally dynamic genome: Evidence of genetic influences on increases and decreases in conduct problems from early childhood to adolescence. Scientific Reports. 2015 May 6;5. 10053. https://doi.org/10.1038/srep10053

Author

Pingault, Jean-Baptiste ; Rijsdijk, Frühling ; Zheng, Yao ; Plomin, Robert ; Viding, Essi. / Developmentally dynamic genome : Evidence of genetic influences on increases and decreases in conduct problems from early childhood to adolescence. In: Scientific Reports. 2015 ; Vol. 5.

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@article{a27c732650084ebbbe19c6e8878c0148,
title = "Developmentally dynamic genome: Evidence of genetic influences on increases and decreases in conduct problems from early childhood to adolescence",
abstract = "The development of conduct problems in childhood and adolescence is associated with adverse long-term outcomes, including psychiatric morbidity. Although genes constitute a proven factor of stability in conduct problems, less is known regarding their role in conduct problems{\textquoteright} developmental course (i.e. systematic age changes, for instance linear increases or decreases).Mothers rated conduct problems from age 4 to 16 years in 10,038 twin pairs from the Twins Early Development Study. Individual differences in the baseline level (.78; 95% CI: .68-.88) and the developmental course of conduct problems (.73; 95% CI: .60-.86) were under high and largely independent additive genetic influences. Shared environment made a small contribution to the baseline level but not to the developmental course of conduct problems. These results show that genetic influences not only contribute to behavioural stability but also explain systematic change in conduct problems. Different sets of genes may be associated with the developmental course versus the baseline level of conduct problems. The structure of genetic and environmental influences on the development of conduct problems suggests that repeated preventive interventions at different developmental stages might be necessary to achieve a long-term impact.",
author = "Jean-Baptiste Pingault and Fr{\"u}hling Rijsdijk and Yao Zheng and Robert Plomin and Essi Viding",
year = "2015",
month = may,
day = "6",
doi = "10.1038/srep10053",
language = "English",
volume = "5",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Developmentally dynamic genome

T2 - Evidence of genetic influences on increases and decreases in conduct problems from early childhood to adolescence

AU - Pingault, Jean-Baptiste

AU - Rijsdijk, Frühling

AU - Zheng, Yao

AU - Plomin, Robert

AU - Viding, Essi

PY - 2015/5/6

Y1 - 2015/5/6

N2 - The development of conduct problems in childhood and adolescence is associated with adverse long-term outcomes, including psychiatric morbidity. Although genes constitute a proven factor of stability in conduct problems, less is known regarding their role in conduct problems’ developmental course (i.e. systematic age changes, for instance linear increases or decreases).Mothers rated conduct problems from age 4 to 16 years in 10,038 twin pairs from the Twins Early Development Study. Individual differences in the baseline level (.78; 95% CI: .68-.88) and the developmental course of conduct problems (.73; 95% CI: .60-.86) were under high and largely independent additive genetic influences. Shared environment made a small contribution to the baseline level but not to the developmental course of conduct problems. These results show that genetic influences not only contribute to behavioural stability but also explain systematic change in conduct problems. Different sets of genes may be associated with the developmental course versus the baseline level of conduct problems. The structure of genetic and environmental influences on the development of conduct problems suggests that repeated preventive interventions at different developmental stages might be necessary to achieve a long-term impact.

AB - The development of conduct problems in childhood and adolescence is associated with adverse long-term outcomes, including psychiatric morbidity. Although genes constitute a proven factor of stability in conduct problems, less is known regarding their role in conduct problems’ developmental course (i.e. systematic age changes, for instance linear increases or decreases).Mothers rated conduct problems from age 4 to 16 years in 10,038 twin pairs from the Twins Early Development Study. Individual differences in the baseline level (.78; 95% CI: .68-.88) and the developmental course of conduct problems (.73; 95% CI: .60-.86) were under high and largely independent additive genetic influences. Shared environment made a small contribution to the baseline level but not to the developmental course of conduct problems. These results show that genetic influences not only contribute to behavioural stability but also explain systematic change in conduct problems. Different sets of genes may be associated with the developmental course versus the baseline level of conduct problems. The structure of genetic and environmental influences on the development of conduct problems suggests that repeated preventive interventions at different developmental stages might be necessary to achieve a long-term impact.

U2 - 10.1038/srep10053

DO - 10.1038/srep10053

M3 - Article

VL - 5

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

M1 - 10053

ER -

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