Devices for Episodic Migraine: Past, Present, and Future

TY - JOUR

T1 - Devices for Episodic Migraine

T2 - Past, Present, and Future

AU - Moreno-Ajona, David

AU - Hoffmann, Jan

AU - Akerman, Simon

N1 - Funding Information: Simon Akerman is supported by a National Institute of Neurological Disorders and Stroke (NINDS) grant, NS120930. Publisher Copyright: © 2022, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

PY - 2022/3

Y1 - 2022/3

N2 - Purpose of Review: Historically, therapies for migraine have generally involved pharmacological treatments using non-selective or selective analgesics and preventive treatments. However, for many patients these treatments are not effective, while others prefer to use non-pharmacological-based therapies. To fill this need, over the last 15 years, neuromodulatory devices have entered the market for migraine treatment. Here, we will review the most recent findings for the use of these devices in the treatment of migraine. Recent Findings: Non-invasive vagus nerve stimulation and spring-pulse transcranial magnetic stimulation are both cleared for the treatment of migraine, supported by preclinical studies that validate efficacy and mechanism of action, and complemented with clinical trial data. Other options also authorized for use include transcutaneous supraorbital nerve stimulation and remote electrical neuromodulation. Summary: Various options are available to treat migraine using authorized neuromodulatory devices. These data support their efficacy in the treatment of episodic migraine, although further studies are necessary to elucidate their mechanism of action and to provide rigor to clinical trial data.

AB - Purpose of Review: Historically, therapies for migraine have generally involved pharmacological treatments using non-selective or selective analgesics and preventive treatments. However, for many patients these treatments are not effective, while others prefer to use non-pharmacological-based therapies. To fill this need, over the last 15 years, neuromodulatory devices have entered the market for migraine treatment. Here, we will review the most recent findings for the use of these devices in the treatment of migraine. Recent Findings: Non-invasive vagus nerve stimulation and spring-pulse transcranial magnetic stimulation are both cleared for the treatment of migraine, supported by preclinical studies that validate efficacy and mechanism of action, and complemented with clinical trial data. Other options also authorized for use include transcutaneous supraorbital nerve stimulation and remote electrical neuromodulation. Summary: Various options are available to treat migraine using authorized neuromodulatory devices. These data support their efficacy in the treatment of episodic migraine, although further studies are necessary to elucidate their mechanism of action and to provide rigor to clinical trial data.

UR - https://www.scopus.com/pages/publications/85124622856

U2 - 10.1007/s11916-022-01024-y

DO - 10.1007/s11916-022-01024-y

M3 - Review article

C2 - 35147856

AN - SCOPUS:85124622856

SN - 1531-3433

VL - 26

SP - 259

EP - 265

JO - Current pain and headache reports

JF - Current pain and headache reports

IS - 3

ER -