Diabetic nephropathy: perspective on novel molecular mechanisms

Luigi Gnudi; Richard Coward; David Long

doi:10.1016/j.tem.2016.07.002

Diabetic nephropathy: perspective on novel molecular mechanisms

Luigi Gnudi, Richard Coward, David Long

Research output: Contribution to journal › Literature review › peer-review

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Abstract

Diabetes is the major cause of end stage renal disease globally, and novel treatments are urgently needed. Current therapeutic approaches for diabetic nephropathy are focusing on the inhibition of the renin angiotensin aldosterone system, on glycaemic and lipid control, and life style changes. In this review we will highlight new molecular insights in our understanding of the initiation and progression of diabetic nephropathy including glomerular insulin resistance, dysregulation of cellular substrate utilisation, podocyte-endothelial communication and inhibition of tubular sodium coupled glucose reabsorption. We believe these mechanisms offer new therapeutic targets that can be exploited to develop important renoprotective treatments for diabetic nephropathy over the next decade.

Original language	English
Journal	TRENDS IN ENDOCRINOLOGY AND METABOLISM
Early online date	25 Jul 2016
DOIs	https://doi.org/10.1016/j.tem.2016.07.002
Publication status	E-pub ahead of print - 25 Jul 2016

Keywords

Diabetes
glomerulus
Oxidative Stress
podocytes
Endothelium
SGLT2

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.tem.2016.07.002

Diabetic Nephropathy: Perspective on_GNUDI_Accepted7July2016_GREEN AAMAccepted author manuscript, 1.31 MBLicence: CC BY-NC-ND

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abstract = "Diabetes is the major cause of end stage renal disease globally, and novel treatments are urgently needed. Current therapeutic approaches for diabetic nephropathy are focusing on the inhibition of the renin angiotensin aldosterone system, on glycaemic and lipid control, and life style changes. In this review we will highlight new molecular insights in our understanding of the initiation and progression of diabetic nephropathy including glomerular insulin resistance, dysregulation of cellular substrate utilisation, podocyte-endothelial communication and inhibition of tubular sodium coupled glucose reabsorption. We believe these mechanisms offer new therapeutic targets that can be exploited to develop important renoprotective treatments for diabetic nephropathy over the next decade. ",

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T1 - Diabetic nephropathy: perspective on novel molecular mechanisms

AU - Gnudi, Luigi

AU - Coward, Richard

AU - Long, David

PY - 2016/7/25

Y1 - 2016/7/25

N2 - Diabetes is the major cause of end stage renal disease globally, and novel treatments are urgently needed. Current therapeutic approaches for diabetic nephropathy are focusing on the inhibition of the renin angiotensin aldosterone system, on glycaemic and lipid control, and life style changes. In this review we will highlight new molecular insights in our understanding of the initiation and progression of diabetic nephropathy including glomerular insulin resistance, dysregulation of cellular substrate utilisation, podocyte-endothelial communication and inhibition of tubular sodium coupled glucose reabsorption. We believe these mechanisms offer new therapeutic targets that can be exploited to develop important renoprotective treatments for diabetic nephropathy over the next decade.

AB - Diabetes is the major cause of end stage renal disease globally, and novel treatments are urgently needed. Current therapeutic approaches for diabetic nephropathy are focusing on the inhibition of the renin angiotensin aldosterone system, on glycaemic and lipid control, and life style changes. In this review we will highlight new molecular insights in our understanding of the initiation and progression of diabetic nephropathy including glomerular insulin resistance, dysregulation of cellular substrate utilisation, podocyte-endothelial communication and inhibition of tubular sodium coupled glucose reabsorption. We believe these mechanisms offer new therapeutic targets that can be exploited to develop important renoprotective treatments for diabetic nephropathy over the next decade.

KW - Diabetes

KW - glomerulus

KW - Oxidative Stress

KW - podocytes

KW - Endothelium

KW - SGLT2

U2 - 10.1016/j.tem.2016.07.002

DO - 10.1016/j.tem.2016.07.002

M3 - Literature review

SN - 1043-2760

JO - TRENDS IN ENDOCRINOLOGY AND METABOLISM

JF - TRENDS IN ENDOCRINOLOGY AND METABOLISM

ER -

Diabetic nephropathy: perspective on novel molecular mechanisms

Abstract

Keywords

UN SDGs

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