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Diagnosis of Autism Spectrum Disorder After Age 5 in Children Evaluated Longitudinally Since Infancy

Research output: Contribution to journalArticle

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Diagnosis of Autism Spectrum Disorder After Age 5 in Children Evaluated Longitudinally Since Infancy. / Ozonoff, Sally; Young, Gregory S.; Brian, Jessica; Charman, Tony; Shephard, Elizabeth; Solish, Abbie; Zwaigenbaum, Lonnie.

In: Journal of the American Academy of Child and Adolescent Psychiatry, 03.09.2018.

Research output: Contribution to journalArticle

Harvard

Ozonoff, S, Young, GS, Brian, J, Charman, T, Shephard, E, Solish, A & Zwaigenbaum, L 2018, 'Diagnosis of Autism Spectrum Disorder After Age 5 in Children Evaluated Longitudinally Since Infancy', Journal of the American Academy of Child and Adolescent Psychiatry. https://doi.org/10.1016/j.jaac.2018.06.022

APA

Ozonoff, S., Young, G. S., Brian, J., Charman, T., Shephard, E., Solish, A., & Zwaigenbaum, L. (2018). Diagnosis of Autism Spectrum Disorder After Age 5 in Children Evaluated Longitudinally Since Infancy. Journal of the American Academy of Child and Adolescent Psychiatry. https://doi.org/10.1016/j.jaac.2018.06.022

Vancouver

Ozonoff S, Young GS, Brian J, Charman T, Shephard E, Solish A et al. Diagnosis of Autism Spectrum Disorder After Age 5 in Children Evaluated Longitudinally Since Infancy. Journal of the American Academy of Child and Adolescent Psychiatry. 2018 Sep 3. https://doi.org/10.1016/j.jaac.2018.06.022

Author

Ozonoff, Sally ; Young, Gregory S. ; Brian, Jessica ; Charman, Tony ; Shephard, Elizabeth ; Solish, Abbie ; Zwaigenbaum, Lonnie. / Diagnosis of Autism Spectrum Disorder After Age 5 in Children Evaluated Longitudinally Since Infancy. In: Journal of the American Academy of Child and Adolescent Psychiatry. 2018.

Bibtex Download

@article{f7b41485134648138024d01a3fab99ed,
title = "Diagnosis of Autism Spectrum Disorder After Age 5 in Children Evaluated Longitudinally Since Infancy",
abstract = "Objective The diagnosis of autism spectrum disorder (ASD) has been found to be remarkably stable but few studies have followed children not initially diagnosed with ASD beyond age 3 to examine late or delayed diagnoses. The current study used a prospective familial-risk design to identify children who had undergone multiple comprehensive assessments in preschool and were determined to be ASD-negative, only to meet criteria for ASD when tested in middle childhood. Method Data were pooled across three research teams studying later-born siblings of children with ASD. Fourteen children met inclusion criteria for the Late Diagnosed group and were compared to a large sample of high- and low-risk siblings from the same sites who had ASD or typical development (TD) outcomes at age 3. Results As a group, the Late Diagnosed children scored between the TD and ASD groups on most measures administered at age 3 and differed significantly from the ASD group on most measures. However, there was significant heterogeneity among the Late Diagnosed cases. Seven showed very little evidence of ASD in preschool, while seven demonstrated subtle, subthreshold symptomatology. Conclusion Some children with ASD may present with a subtle phenotype early in life or show a prolonged time course of symptom development. This emphasizes the need for screening and surveillance schedules that extend past 36 months and continued evaluation of any child who presents with atypical early development and/or high-risk status. The findings also shed light on reasons why the mean age of ASD diagnosis remains over 4 years.",
keywords = "autism spectrum disorder, diagnosis, diagnostic stability",
author = "Sally Ozonoff and Young, {Gregory S.} and Jessica Brian and Tony Charman and Elizabeth Shephard and Abbie Solish and Lonnie Zwaigenbaum",
year = "2018",
month = sep,
day = "3",
doi = "10.1016/j.jaac.2018.06.022",
language = "English",
journal = "Journal of the American Academy of Child and Adolescent Psychiatry",
issn = "0890-8567",
publisher = "Elsevier Limited",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Diagnosis of Autism Spectrum Disorder After Age 5 in Children Evaluated Longitudinally Since Infancy

AU - Ozonoff, Sally

AU - Young, Gregory S.

AU - Brian, Jessica

AU - Charman, Tony

AU - Shephard, Elizabeth

AU - Solish, Abbie

AU - Zwaigenbaum, Lonnie

PY - 2018/9/3

Y1 - 2018/9/3

N2 - Objective The diagnosis of autism spectrum disorder (ASD) has been found to be remarkably stable but few studies have followed children not initially diagnosed with ASD beyond age 3 to examine late or delayed diagnoses. The current study used a prospective familial-risk design to identify children who had undergone multiple comprehensive assessments in preschool and were determined to be ASD-negative, only to meet criteria for ASD when tested in middle childhood. Method Data were pooled across three research teams studying later-born siblings of children with ASD. Fourteen children met inclusion criteria for the Late Diagnosed group and were compared to a large sample of high- and low-risk siblings from the same sites who had ASD or typical development (TD) outcomes at age 3. Results As a group, the Late Diagnosed children scored between the TD and ASD groups on most measures administered at age 3 and differed significantly from the ASD group on most measures. However, there was significant heterogeneity among the Late Diagnosed cases. Seven showed very little evidence of ASD in preschool, while seven demonstrated subtle, subthreshold symptomatology. Conclusion Some children with ASD may present with a subtle phenotype early in life or show a prolonged time course of symptom development. This emphasizes the need for screening and surveillance schedules that extend past 36 months and continued evaluation of any child who presents with atypical early development and/or high-risk status. The findings also shed light on reasons why the mean age of ASD diagnosis remains over 4 years.

AB - Objective The diagnosis of autism spectrum disorder (ASD) has been found to be remarkably stable but few studies have followed children not initially diagnosed with ASD beyond age 3 to examine late or delayed diagnoses. The current study used a prospective familial-risk design to identify children who had undergone multiple comprehensive assessments in preschool and were determined to be ASD-negative, only to meet criteria for ASD when tested in middle childhood. Method Data were pooled across three research teams studying later-born siblings of children with ASD. Fourteen children met inclusion criteria for the Late Diagnosed group and were compared to a large sample of high- and low-risk siblings from the same sites who had ASD or typical development (TD) outcomes at age 3. Results As a group, the Late Diagnosed children scored between the TD and ASD groups on most measures administered at age 3 and differed significantly from the ASD group on most measures. However, there was significant heterogeneity among the Late Diagnosed cases. Seven showed very little evidence of ASD in preschool, while seven demonstrated subtle, subthreshold symptomatology. Conclusion Some children with ASD may present with a subtle phenotype early in life or show a prolonged time course of symptom development. This emphasizes the need for screening and surveillance schedules that extend past 36 months and continued evaluation of any child who presents with atypical early development and/or high-risk status. The findings also shed light on reasons why the mean age of ASD diagnosis remains over 4 years.

KW - autism spectrum disorder

KW - diagnosis

KW - diagnostic stability

U2 - 10.1016/j.jaac.2018.06.022

DO - 10.1016/j.jaac.2018.06.022

M3 - Article

JO - Journal of the American Academy of Child and Adolescent Psychiatry

JF - Journal of the American Academy of Child and Adolescent Psychiatry

SN - 0890-8567

ER -

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