Diagnosis of post-transplant lymphoproliferative disorder in solid organ transplant recipients - BCSH and BTS Guidelines

Anne Parker; Kristin Bowles; J. Andrew Bradley; Vincent Emery; Carrie Featherstone; Girish Gupte; Robert Marcus; Jayan Parameshwar; Alan Ramsay; Charles Newstead; British Comm Stand Haematol; British Transplantation Soc

doi:10.1111/j.1365-2141.2010.08161.x

Diagnosis of post-transplant lymphoproliferative disorder in solid organ transplant recipients - BCSH and BTS Guidelines

Anne Parker^*, Kristin Bowles, J. Andrew Bradley, Vincent Emery, Carrie Featherstone, Girish Gupte, Robert Marcus, Jayan Parameshwar, Alan Ramsay, Charles Newstead, British Comm Stand Haematol, British Transplantation Soc

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

198 Citations (Scopus)

Abstract

A joint working group established by the Haemato-oncology subgroup of the British Committee for Standards in Haematology (BCSH) and the British Transplantation Society (BTS) has reviewed the available literature and made recommendations for the diagnosis and management of post-transplant lymphoproliferative disorder (PTLD) in adult recipients of solid organ transplants. This review details the risk factors predisposing to development, initial features and diagnosis. It is important that the risk of developing PTLD is considered when using post transplant immunosuppression and that the appropriate investigations are carried out when there are suspicions of the diagnosis. These must include tissue for histology and computed tomography scan to assess the extent of disease. These recommendations have been made primarily for adult patients, there have been some comments made with regard to paediatric practice.

Original language	English
Pages (from-to)	675-692
Number of pages	18
Journal	British Journal of Haematology
Volume	149
Issue number	5
DOIs	https://doi.org/10.1111/j.1365-2141.2010.08161.x
Publication status	Published - Jun 2010

Keywords

Transplant
lymphoproliferative disease
diagnostic haematology
EBV
EPSTEIN-BARR-VIRUS
POSITRON-EMISSION-TOMOGRAPHY
CYTOTOXIC-T-CELLS
FINE-NEEDLE ASPIRATION
LIVER-TRANSPLANTATION
RENAL-TRANSPLANTATION
VIRAL LOAD
FDG-PET
HEART-TRANSPLANTATION
INDUCTION THERAPY

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Parker, A., Bowles, K., Bradley, J. A., Emery, V., Featherstone, C., Gupte, G., Marcus, R., Parameshwar, J., Ramsay, A., Newstead, C., British Comm Stand Haematol, & British Transplantation Soc (2010). Diagnosis of post-transplant lymphoproliferative disorder in solid organ transplant recipients - BCSH and BTS Guidelines. British Journal of Haematology, 149(5), 675-692. https://doi.org/10.1111/j.1365-2141.2010.08161.x

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abstract = "A joint working group established by the Haemato-oncology subgroup of the British Committee for Standards in Haematology (BCSH) and the British Transplantation Society (BTS) has reviewed the available literature and made recommendations for the diagnosis and management of post-transplant lymphoproliferative disorder (PTLD) in adult recipients of solid organ transplants. This review details the risk factors predisposing to development, initial features and diagnosis. It is important that the risk of developing PTLD is considered when using post transplant immunosuppression and that the appropriate investigations are carried out when there are suspicions of the diagnosis. These must include tissue for histology and computed tomography scan to assess the extent of disease. These recommendations have been made primarily for adult patients, there have been some comments made with regard to paediatric practice.",

keywords = "Transplant, lymphoproliferative disease, diagnostic haematology, EBV, EPSTEIN-BARR-VIRUS, POSITRON-EMISSION-TOMOGRAPHY, CYTOTOXIC-T-CELLS, FINE-NEEDLE ASPIRATION, LIVER-TRANSPLANTATION, RENAL-TRANSPLANTATION, VIRAL LOAD, FDG-PET, HEART-TRANSPLANTATION, INDUCTION THERAPY",

author = "Anne Parker and Kristin Bowles and Bradley, {J. Andrew} and Vincent Emery and Carrie Featherstone and Girish Gupte and Robert Marcus and Jayan Parameshwar and Alan Ramsay and Charles Newstead and {British Comm Stand Haematol} and {British Transplantation Soc}",

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Parker, A, Bowles, K, Bradley, JA, Emery, V, Featherstone, C, Gupte, G, Marcus, R, Parameshwar, J, Ramsay, A, Newstead, C, British Comm Stand Haematol & British Transplantation Soc 2010, 'Diagnosis of post-transplant lymphoproliferative disorder in solid organ transplant recipients - BCSH and BTS Guidelines', British Journal of Haematology, vol. 149, no. 5, pp. 675-692. https://doi.org/10.1111/j.1365-2141.2010.08161.x

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AU - Parker, Anne

AU - Bowles, Kristin

AU - Bradley, J. Andrew

AU - Emery, Vincent

AU - Featherstone, Carrie

AU - Gupte, Girish

AU - Marcus, Robert

AU - Parameshwar, Jayan

AU - Ramsay, Alan

AU - Newstead, Charles

AU - British Comm Stand Haematol

AU - British Transplantation Soc

PY - 2010/6

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N2 - A joint working group established by the Haemato-oncology subgroup of the British Committee for Standards in Haematology (BCSH) and the British Transplantation Society (BTS) has reviewed the available literature and made recommendations for the diagnosis and management of post-transplant lymphoproliferative disorder (PTLD) in adult recipients of solid organ transplants. This review details the risk factors predisposing to development, initial features and diagnosis. It is important that the risk of developing PTLD is considered when using post transplant immunosuppression and that the appropriate investigations are carried out when there are suspicions of the diagnosis. These must include tissue for histology and computed tomography scan to assess the extent of disease. These recommendations have been made primarily for adult patients, there have been some comments made with regard to paediatric practice.

AB - A joint working group established by the Haemato-oncology subgroup of the British Committee for Standards in Haematology (BCSH) and the British Transplantation Society (BTS) has reviewed the available literature and made recommendations for the diagnosis and management of post-transplant lymphoproliferative disorder (PTLD) in adult recipients of solid organ transplants. This review details the risk factors predisposing to development, initial features and diagnosis. It is important that the risk of developing PTLD is considered when using post transplant immunosuppression and that the appropriate investigations are carried out when there are suspicions of the diagnosis. These must include tissue for histology and computed tomography scan to assess the extent of disease. These recommendations have been made primarily for adult patients, there have been some comments made with regard to paediatric practice.

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KW - diagnostic haematology

KW - EBV

KW - EPSTEIN-BARR-VIRUS

KW - POSITRON-EMISSION-TOMOGRAPHY

KW - CYTOTOXIC-T-CELLS

KW - FINE-NEEDLE ASPIRATION

KW - LIVER-TRANSPLANTATION

KW - RENAL-TRANSPLANTATION

KW - VIRAL LOAD

KW - FDG-PET

KW - HEART-TRANSPLANTATION

KW - INDUCTION THERAPY

U2 - 10.1111/j.1365-2141.2010.08161.x

DO - 10.1111/j.1365-2141.2010.08161.x

M3 - Article

SN - 0007-1048

VL - 149

SP - 675

EP - 692

JO - British Journal of Haematology

JF - British Journal of Haematology

IS - 5

ER -

Diagnosis of post-transplant lymphoproliferative disorder in solid organ transplant recipients - BCSH and BTS Guidelines

Abstract

Keywords

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