TY - JOUR
T1 - Diagnosis, prognosis, and treatment of brief psychotic episodes: a review and research agenda
AU - Fusar-Poli, Paolo
AU - Salazar de pablo, Gonzalo
AU - Rajkumar, Ravi Philip
AU - López-Díaz, Álvaro
AU - Malhotra, Savita
AU - Heckers, Stephan
AU - Lawrie, Stephen M
AU - Pillmann, Frank
N1 - Funding Information:
This study is supported by a Wellcome Trust grant (215793/Z/19/Z) to PFP. GSdP is supported by the Alicia Koplowitz Foundation.
Funding Information:
PFP received grant support from Lundbeck and honoraria fees from Angelini, Menarini, and Lundbeck, outside the submitted work. SML has received personal fees from Sunovion, outside the submitted work.
Publisher Copyright:
© 2022 Elsevier Ltd
PY - 2022/1/1
Y1 - 2022/1/1
N2 - Brief psychotic episodes represent an intriguing paradox in clinical psychiatry because they elude the standard knowledge that applies to the persisting psychotic disorders such as schizophrenia. This Review describes key diagnostic considerations such as conceptual foundations, current psychiatric classification versus research-based operationalisations, epidemiology, and sociocultural variations; prognostic aspects including the risk of psychosis recurrence, types of psychotic recurrences, other clinical outcomes, prognostic factors; and therapeutic issues such as treatment guidelines and unmet need of care. The advances and challenges associated with the scientific evidence are used to set a research agenda in this area. We conclude that brief psychotic episodes can be reconceptualised within a clinical staging model to promote innovative translational research and improve our understanding and treatment of psychotic disorders.
AB - Brief psychotic episodes represent an intriguing paradox in clinical psychiatry because they elude the standard knowledge that applies to the persisting psychotic disorders such as schizophrenia. This Review describes key diagnostic considerations such as conceptual foundations, current psychiatric classification versus research-based operationalisations, epidemiology, and sociocultural variations; prognostic aspects including the risk of psychosis recurrence, types of psychotic recurrences, other clinical outcomes, prognostic factors; and therapeutic issues such as treatment guidelines and unmet need of care. The advances and challenges associated with the scientific evidence are used to set a research agenda in this area. We conclude that brief psychotic episodes can be reconceptualised within a clinical staging model to promote innovative translational research and improve our understanding and treatment of psychotic disorders.
UR - http://www.scopus.com/inward/record.url?scp=85121145927&partnerID=8YFLogxK
U2 - 10.1016/S2215-0366(21)00121-8
DO - 10.1016/S2215-0366(21)00121-8
M3 - Review article
SN - 2215-0366
VL - 9
SP - 72
EP - 83
JO - The Lancet Psychiatry
JF - The Lancet Psychiatry
IS - 1
ER -