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Diagnostic accuracy of placental growth factor and ultrasound parameters to predict the small-for-gestational-age infant in women presenting with reduced symphysis-fundus height

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Diagnostic accuracy of placental growth factor and ultrasound parameters to predict the small-for-gestational-age infant in women presenting with reduced symphysis-fundus height. / Griffin, M.; Seed, P. T.; Webster, L.; Myers, J.; Mackillop, L.; Simpson, N.; Anumba, D.; Khalil, A.; Denbow, M.; Sau, A.; Hinshaw, K.; Von Dadelszen, P.; Benton, S.; Girling, J.; Redman, C. W G; Chappell, L. C.; Shennan, A. H.

In: Ultrasound in Obstetrics and Gynecology, Vol. 46, No. 2, 01.08.2015, p. 182-190.

Research output: Contribution to journalArticle

Harvard

Griffin, M, Seed, PT, Webster, L, Myers, J, Mackillop, L, Simpson, N, Anumba, D, Khalil, A, Denbow, M, Sau, A, Hinshaw, K, Von Dadelszen, P, Benton, S, Girling, J, Redman, CWG, Chappell, LC & Shennan, AH 2015, 'Diagnostic accuracy of placental growth factor and ultrasound parameters to predict the small-for-gestational-age infant in women presenting with reduced symphysis-fundus height', Ultrasound in Obstetrics and Gynecology, vol. 46, no. 2, pp. 182-190. https://doi.org/10.1002/uog.14860

APA

Griffin, M., Seed, P. T., Webster, L., Myers, J., Mackillop, L., Simpson, N., ... Shennan, A. H. (2015). Diagnostic accuracy of placental growth factor and ultrasound parameters to predict the small-for-gestational-age infant in women presenting with reduced symphysis-fundus height. Ultrasound in Obstetrics and Gynecology, 46(2), 182-190. https://doi.org/10.1002/uog.14860

Vancouver

Griffin M, Seed PT, Webster L, Myers J, Mackillop L, Simpson N et al. Diagnostic accuracy of placental growth factor and ultrasound parameters to predict the small-for-gestational-age infant in women presenting with reduced symphysis-fundus height. Ultrasound in Obstetrics and Gynecology. 2015 Aug 1;46(2):182-190. https://doi.org/10.1002/uog.14860

Author

Griffin, M. ; Seed, P. T. ; Webster, L. ; Myers, J. ; Mackillop, L. ; Simpson, N. ; Anumba, D. ; Khalil, A. ; Denbow, M. ; Sau, A. ; Hinshaw, K. ; Von Dadelszen, P. ; Benton, S. ; Girling, J. ; Redman, C. W G ; Chappell, L. C. ; Shennan, A. H. / Diagnostic accuracy of placental growth factor and ultrasound parameters to predict the small-for-gestational-age infant in women presenting with reduced symphysis-fundus height. In: Ultrasound in Obstetrics and Gynecology. 2015 ; Vol. 46, No. 2. pp. 182-190.

Bibtex Download

@article{9ce894cec6184b75b4e644e1daa61bbb,
title = "Diagnostic accuracy of placental growth factor and ultrasound parameters to predict the small-for-gestational-age infant in women presenting with reduced symphysis-fundus height",
abstract = "ObjectivesTo assess the diagnostic accuracy of placental growth factor (PlGF) and ultrasound parameters to predict delivery of a small-for-gestational-age (SGA) infant in women presenting with reduced symphysis-fundus height (SFH). MethodsThis was a multicenter prospective observational study recruiting 601 women with a singleton pregnancy and reduced SFH between 24 and 37 weeks' gestation across 11 sites in the UK and Canada. Plasma PlGF concentration < 5th centile, estimated fetal weight (EFW) < 10th centile, umbilical artery Doppler pulsatility index > 95th centile and oligohydramnios (amniotic fluid index < 5 cm) were compared as predictors for a SGA infant < 3rd customized birth-weight centile and adverse perinatal outcome. Test performance statistics were calculated for all parameters in isolation and in combination. Results Of the 601 women recruited, 592 were analyzed. For predicting delivery of SGA < 3rd centile (n = 78), EFW < 10th centile had 58{\%} sensitivity (95{\%} CI, 46-69{\%}) and 93{\%} negative predictive value (NPV) (95{\%} CI, 90-95{\%}), PlGF had 37{\%} sensitivity (95{\%} CI, 27-49{\%}) and 90{\%} NPV (95{\%} CI, 87-93{\%}); in combination, PlGF and EFW < 10th centile had 69{\%} sensitivity (95{\%} CI, 55-81{\%}) and 93{\%} NPV (95{\%} CI, 89-96{\%}). The equivalent receiver-operating characteristics (ROC) curve areas were 0.79 (95{\%} CI, 0.74-0.84) for EFW < 10th centile, 0.70 (95{\%} CI, 0.63-0.77) for low PlGF and 0.82 (95{\%} CI, 0.77-0.86) in combination.ConclusionsFor women presenting with reduced SFH, ultrasound parameters had modest test performance for predicting delivery of SGA < 3rd centile. PlGF performed no better than EFW < 10th centile in determining delivery of a SGA infant.",
keywords = "estimated fetal weight, fetal growth restriction, placental growth factor, small-for-gestational age",
author = "M. Griffin and Seed, {P. T.} and L. Webster and J. Myers and L. Mackillop and N. Simpson and D. Anumba and A. Khalil and M. Denbow and A. Sau and K. Hinshaw and {Von Dadelszen}, P. and S. Benton and J. Girling and Redman, {C. W G} and Chappell, {L. C.} and Shennan, {A. H.}",
note = "{\circledC} 2015 The Authors. Ultrasound in Obstetrics & Gynecology published by John Wiley & Sons Ltd on behalf of the international society of ultrasound in obstetrics and gynecology.",
year = "2015",
month = "8",
day = "1",
doi = "10.1002/uog.14860",
language = "English",
volume = "46",
pages = "182--190",
journal = "Ultrasound in Obstetrics and Gynecology",
issn = "0960-7692",
publisher = "John Wiley and Sons Ltd",
number = "2",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Diagnostic accuracy of placental growth factor and ultrasound parameters to predict the small-for-gestational-age infant in women presenting with reduced symphysis-fundus height

AU - Griffin, M.

AU - Seed, P. T.

AU - Webster, L.

AU - Myers, J.

AU - Mackillop, L.

AU - Simpson, N.

AU - Anumba, D.

AU - Khalil, A.

AU - Denbow, M.

AU - Sau, A.

AU - Hinshaw, K.

AU - Von Dadelszen, P.

AU - Benton, S.

AU - Girling, J.

AU - Redman, C. W G

AU - Chappell, L. C.

AU - Shennan, A. H.

N1 - © 2015 The Authors. Ultrasound in Obstetrics & Gynecology published by John Wiley & Sons Ltd on behalf of the international society of ultrasound in obstetrics and gynecology.

PY - 2015/8/1

Y1 - 2015/8/1

N2 - ObjectivesTo assess the diagnostic accuracy of placental growth factor (PlGF) and ultrasound parameters to predict delivery of a small-for-gestational-age (SGA) infant in women presenting with reduced symphysis-fundus height (SFH). MethodsThis was a multicenter prospective observational study recruiting 601 women with a singleton pregnancy and reduced SFH between 24 and 37 weeks' gestation across 11 sites in the UK and Canada. Plasma PlGF concentration < 5th centile, estimated fetal weight (EFW) < 10th centile, umbilical artery Doppler pulsatility index > 95th centile and oligohydramnios (amniotic fluid index < 5 cm) were compared as predictors for a SGA infant < 3rd customized birth-weight centile and adverse perinatal outcome. Test performance statistics were calculated for all parameters in isolation and in combination. Results Of the 601 women recruited, 592 were analyzed. For predicting delivery of SGA < 3rd centile (n = 78), EFW < 10th centile had 58% sensitivity (95% CI, 46-69%) and 93% negative predictive value (NPV) (95% CI, 90-95%), PlGF had 37% sensitivity (95% CI, 27-49%) and 90% NPV (95% CI, 87-93%); in combination, PlGF and EFW < 10th centile had 69% sensitivity (95% CI, 55-81%) and 93% NPV (95% CI, 89-96%). The equivalent receiver-operating characteristics (ROC) curve areas were 0.79 (95% CI, 0.74-0.84) for EFW < 10th centile, 0.70 (95% CI, 0.63-0.77) for low PlGF and 0.82 (95% CI, 0.77-0.86) in combination.ConclusionsFor women presenting with reduced SFH, ultrasound parameters had modest test performance for predicting delivery of SGA < 3rd centile. PlGF performed no better than EFW < 10th centile in determining delivery of a SGA infant.

AB - ObjectivesTo assess the diagnostic accuracy of placental growth factor (PlGF) and ultrasound parameters to predict delivery of a small-for-gestational-age (SGA) infant in women presenting with reduced symphysis-fundus height (SFH). MethodsThis was a multicenter prospective observational study recruiting 601 women with a singleton pregnancy and reduced SFH between 24 and 37 weeks' gestation across 11 sites in the UK and Canada. Plasma PlGF concentration < 5th centile, estimated fetal weight (EFW) < 10th centile, umbilical artery Doppler pulsatility index > 95th centile and oligohydramnios (amniotic fluid index < 5 cm) were compared as predictors for a SGA infant < 3rd customized birth-weight centile and adverse perinatal outcome. Test performance statistics were calculated for all parameters in isolation and in combination. Results Of the 601 women recruited, 592 were analyzed. For predicting delivery of SGA < 3rd centile (n = 78), EFW < 10th centile had 58% sensitivity (95% CI, 46-69%) and 93% negative predictive value (NPV) (95% CI, 90-95%), PlGF had 37% sensitivity (95% CI, 27-49%) and 90% NPV (95% CI, 87-93%); in combination, PlGF and EFW < 10th centile had 69% sensitivity (95% CI, 55-81%) and 93% NPV (95% CI, 89-96%). The equivalent receiver-operating characteristics (ROC) curve areas were 0.79 (95% CI, 0.74-0.84) for EFW < 10th centile, 0.70 (95% CI, 0.63-0.77) for low PlGF and 0.82 (95% CI, 0.77-0.86) in combination.ConclusionsFor women presenting with reduced SFH, ultrasound parameters had modest test performance for predicting delivery of SGA < 3rd centile. PlGF performed no better than EFW < 10th centile in determining delivery of a SGA infant.

KW - estimated fetal weight

KW - fetal growth restriction

KW - placental growth factor

KW - small-for-gestational age

UR - http://www.scopus.com/inward/record.url?scp=84937970000&partnerID=8YFLogxK

U2 - 10.1002/uog.14860

DO - 10.1002/uog.14860

M3 - Article

AN - SCOPUS:84937970000

VL - 46

SP - 182

EP - 190

JO - Ultrasound in Obstetrics and Gynecology

JF - Ultrasound in Obstetrics and Gynecology

SN - 0960-7692

IS - 2

ER -

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