Dietary intake of inulin-type fructans in active and inactive Crohn's disease and healthy controls: A case-control study

Jacqueline L. Anderson; Charlotte R. Hedin; Jane L. Benjamin; Andreas Koutsoumpas; Siew C. Ng; Ailsa L. Hart; Alastair Forbes; Andrew J. Stagg; James O. Lindsay; Kevin Whelan

doi:10.1093/ecco-jcc/jjv136

Dietary intake of inulin-type fructans in active and inactive Crohn's disease and healthy controls: A case-control study

Jacqueline L. Anderson, Charlotte R. Hedin, Jane L. Benjamin, Andreas Koutsoumpas, Siew C. Ng, Ailsa L. Hart, Alastair Forbes, Andrew J. Stagg, James O. Lindsay, Kevin Whelan^*

^*Corresponding author for this work

Nutritional Sciences

Research output: Contribution to journal › Article › peer-review

38 Citations (Scopus)

Abstract

Background and Aims: Prebiotic inulin-type fructans are widely consumed in the diet and may have contrasting effects in Crohn's disease by stimulating gut microbiota and/or by generating functional gastrointestinal symptoms. The aim of this study was to measure fructan and oligofructose intakes in patients with active and inactive Crohn's disease compared with healthy controls. Methods: Patients with active Crohn's disease (n = 98), inactive Crohn's (n = 99) and healthy controls (n = 106) were recruited to a case-control study. Dietary intake of inulin-type fructans was measured using a specific food frequency questionnaire and was compared between the three groups and between patients with different disease phenotypes (Montreal classification). Associations between intakes and disease activity (Harvey-Bradshaw Index, HBI) were also undertaken. Results: Patients with active Crohn's disease had lower fructan intakes (median 2.9 g/d, interquartile range [IQR] 1.8) than those with inactive Crohn's (3.6 g/d, 2.1, p = 0.036) or controls (3.9 g/d, 2.1, p = 0.003) and lower oligofructose intakes (2.8 g/d, 1.8) than those with inactive Crohn's (3.5 g/d, 2.2, p = 0.048) or controls (3.8 g/d, 2.1, p = 0.003). There were no differences in intakes related to disease site or behaviour. There were negative correlations between HBI well-being score and fructan intake (ρ = -0.154, p = 0.03) and oligofructose intake (ρ = -0.156, p = 0.028) and for the HBI abdominal pain score and fructan (ρ = -0.164, p = 0.021) and oligofructose intake (ρ = -0.157, p = 0.027). Conclusions: Patients with active Crohn's disease consume lower quantities of fructans and oligofructose than their inactive counterparts and healthy controls. The impact of lower intakes of prebiotic fructans on gut microbiota is unknown and warrants further research.

Original language	English
Article number	jjv136
Pages (from-to)	1024-1031
Number of pages	8
Journal	Journal of Crohn's & colitis
Volume	9
Issue number	11
DOIs	https://doi.org/10.1093/ecco-jcc/jjv136
Publication status	Published - 1 Nov 2015

Keywords

FODMAPs
fructans
Inflammatory bowel disease
inulin
oligofructose

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10.1093/ecco-jcc/jjv136

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Anderson, J. L., Hedin, C. R., Benjamin, J. L., Koutsoumpas, A., Ng, S. C., Hart, A. L., Forbes, A., Stagg, A. J., Lindsay, J. O., & Whelan, K. (2015). Dietary intake of inulin-type fructans in active and inactive Crohn's disease and healthy controls: A case-control study. Journal of Crohn's & colitis, 9(11), 1024-1031. Article jjv136. https://doi.org/10.1093/ecco-jcc/jjv136

@article{95a71478a3954fcbabad77b08e20dc89,

title = "Dietary intake of inulin-type fructans in active and inactive Crohn's disease and healthy controls: A case-control study",

abstract = "Background and Aims: Prebiotic inulin-type fructans are widely consumed in the diet and may have contrasting effects in Crohn's disease by stimulating gut microbiota and/or by generating functional gastrointestinal symptoms. The aim of this study was to measure fructan and oligofructose intakes in patients with active and inactive Crohn's disease compared with healthy controls. Methods: Patients with active Crohn's disease (n = 98), inactive Crohn's (n = 99) and healthy controls (n = 106) were recruited to a case-control study. Dietary intake of inulin-type fructans was measured using a specific food frequency questionnaire and was compared between the three groups and between patients with different disease phenotypes (Montreal classification). Associations between intakes and disease activity (Harvey-Bradshaw Index, HBI) were also undertaken. Results: Patients with active Crohn's disease had lower fructan intakes (median 2.9 g/d, interquartile range [IQR] 1.8) than those with inactive Crohn's (3.6 g/d, 2.1, p = 0.036) or controls (3.9 g/d, 2.1, p = 0.003) and lower oligofructose intakes (2.8 g/d, 1.8) than those with inactive Crohn's (3.5 g/d, 2.2, p = 0.048) or controls (3.8 g/d, 2.1, p = 0.003). There were no differences in intakes related to disease site or behaviour. There were negative correlations between HBI well-being score and fructan intake (ρ = -0.154, p = 0.03) and oligofructose intake (ρ = -0.156, p = 0.028) and for the HBI abdominal pain score and fructan (ρ = -0.164, p = 0.021) and oligofructose intake (ρ = -0.157, p = 0.027). Conclusions: Patients with active Crohn's disease consume lower quantities of fructans and oligofructose than their inactive counterparts and healthy controls. The impact of lower intakes of prebiotic fructans on gut microbiota is unknown and warrants further research.",

keywords = "FODMAPs, fructans, Inflammatory bowel disease, inulin, oligofructose",

author = "Anderson, {Jacqueline L.} and Hedin, {Charlotte R.} and Benjamin, {Jane L.} and Andreas Koutsoumpas and Ng, {Siew C.} and Hart, {Ailsa L.} and Alastair Forbes and Stagg, {Andrew J.} and Lindsay, {James O.} and Kevin Whelan",

year = "2015",

month = nov,

day = "1",

doi = "10.1093/ecco-jcc/jjv136",

language = "English",

volume = "9",

pages = "1024--1031",

journal = "Journal of Crohn's & colitis",

issn = "1873-9946",

publisher = "Oxford University Press (OUP)",

number = "11",

}

TY - JOUR

T1 - Dietary intake of inulin-type fructans in active and inactive Crohn's disease and healthy controls

T2 - A case-control study

AU - Anderson, Jacqueline L.

AU - Hedin, Charlotte R.

AU - Benjamin, Jane L.

AU - Koutsoumpas, Andreas

AU - Ng, Siew C.

AU - Hart, Ailsa L.

AU - Forbes, Alastair

AU - Stagg, Andrew J.

AU - Lindsay, James O.

AU - Whelan, Kevin

PY - 2015/11/1

Y1 - 2015/11/1

N2 - Background and Aims: Prebiotic inulin-type fructans are widely consumed in the diet and may have contrasting effects in Crohn's disease by stimulating gut microbiota and/or by generating functional gastrointestinal symptoms. The aim of this study was to measure fructan and oligofructose intakes in patients with active and inactive Crohn's disease compared with healthy controls. Methods: Patients with active Crohn's disease (n = 98), inactive Crohn's (n = 99) and healthy controls (n = 106) were recruited to a case-control study. Dietary intake of inulin-type fructans was measured using a specific food frequency questionnaire and was compared between the three groups and between patients with different disease phenotypes (Montreal classification). Associations between intakes and disease activity (Harvey-Bradshaw Index, HBI) were also undertaken. Results: Patients with active Crohn's disease had lower fructan intakes (median 2.9 g/d, interquartile range [IQR] 1.8) than those with inactive Crohn's (3.6 g/d, 2.1, p = 0.036) or controls (3.9 g/d, 2.1, p = 0.003) and lower oligofructose intakes (2.8 g/d, 1.8) than those with inactive Crohn's (3.5 g/d, 2.2, p = 0.048) or controls (3.8 g/d, 2.1, p = 0.003). There were no differences in intakes related to disease site or behaviour. There were negative correlations between HBI well-being score and fructan intake (ρ = -0.154, p = 0.03) and oligofructose intake (ρ = -0.156, p = 0.028) and for the HBI abdominal pain score and fructan (ρ = -0.164, p = 0.021) and oligofructose intake (ρ = -0.157, p = 0.027). Conclusions: Patients with active Crohn's disease consume lower quantities of fructans and oligofructose than their inactive counterparts and healthy controls. The impact of lower intakes of prebiotic fructans on gut microbiota is unknown and warrants further research.

AB - Background and Aims: Prebiotic inulin-type fructans are widely consumed in the diet and may have contrasting effects in Crohn's disease by stimulating gut microbiota and/or by generating functional gastrointestinal symptoms. The aim of this study was to measure fructan and oligofructose intakes in patients with active and inactive Crohn's disease compared with healthy controls. Methods: Patients with active Crohn's disease (n = 98), inactive Crohn's (n = 99) and healthy controls (n = 106) were recruited to a case-control study. Dietary intake of inulin-type fructans was measured using a specific food frequency questionnaire and was compared between the three groups and between patients with different disease phenotypes (Montreal classification). Associations between intakes and disease activity (Harvey-Bradshaw Index, HBI) were also undertaken. Results: Patients with active Crohn's disease had lower fructan intakes (median 2.9 g/d, interquartile range [IQR] 1.8) than those with inactive Crohn's (3.6 g/d, 2.1, p = 0.036) or controls (3.9 g/d, 2.1, p = 0.003) and lower oligofructose intakes (2.8 g/d, 1.8) than those with inactive Crohn's (3.5 g/d, 2.2, p = 0.048) or controls (3.8 g/d, 2.1, p = 0.003). There were no differences in intakes related to disease site or behaviour. There were negative correlations between HBI well-being score and fructan intake (ρ = -0.154, p = 0.03) and oligofructose intake (ρ = -0.156, p = 0.028) and for the HBI abdominal pain score and fructan (ρ = -0.164, p = 0.021) and oligofructose intake (ρ = -0.157, p = 0.027). Conclusions: Patients with active Crohn's disease consume lower quantities of fructans and oligofructose than their inactive counterparts and healthy controls. The impact of lower intakes of prebiotic fructans on gut microbiota is unknown and warrants further research.

KW - FODMAPs

KW - fructans

KW - Inflammatory bowel disease

KW - inulin

KW - oligofructose

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U2 - 10.1093/ecco-jcc/jjv136

DO - 10.1093/ecco-jcc/jjv136

M3 - Article

C2 - 26221003

AN - SCOPUS:84963751458

SN - 1873-9946

VL - 9

SP - 1024

EP - 1031

JO - Journal of Crohn's & colitis

JF - Journal of Crohn's & colitis

IS - 11

M1 - jjv136

ER -

Dietary intake of inulin-type fructans in active and inactive Crohn's disease and healthy controls: A case-control study

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Keywords

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