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Differences in the link between insulin sensitivity and ectopic fat in men of Black African and White European ethnicity

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Differences in the link between insulin sensitivity and ectopic fat in men of Black African and White European ethnicity. / Bello, Oluwatoyosi; Ladwa, Meera; Hakim, Olah; Marathe, Chinmay; Shojaee-Moradie, Fariba; Charles-Edwards, Geoff; Peacock, Janet L.; Margot Umpleby, A.; Amiel, Stephanie A.; Goff, Louise M.

In: European Journal of Endocrinology, Vol. 182, No. 1, 01.01.2020, p. 91-101.

Research output: Contribution to journalArticle

Harvard

Bello, O, Ladwa, M, Hakim, O, Marathe, C, Shojaee-Moradie, F, Charles-Edwards, G, Peacock, JL, Margot Umpleby, A, Amiel, SA & Goff, LM 2020, 'Differences in the link between insulin sensitivity and ectopic fat in men of Black African and White European ethnicity', European Journal of Endocrinology, vol. 182, no. 1, pp. 91-101. https://doi.org/10.1530/EJE-19-0636

APA

Bello, O., Ladwa, M., Hakim, O., Marathe, C., Shojaee-Moradie, F., Charles-Edwards, G., ... Goff, L. M. (2020). Differences in the link between insulin sensitivity and ectopic fat in men of Black African and White European ethnicity. European Journal of Endocrinology, 182(1), 91-101. https://doi.org/10.1530/EJE-19-0636

Vancouver

Bello O, Ladwa M, Hakim O, Marathe C, Shojaee-Moradie F, Charles-Edwards G et al. Differences in the link between insulin sensitivity and ectopic fat in men of Black African and White European ethnicity. European Journal of Endocrinology. 2020 Jan 1;182(1):91-101. https://doi.org/10.1530/EJE-19-0636

Author

Bello, Oluwatoyosi ; Ladwa, Meera ; Hakim, Olah ; Marathe, Chinmay ; Shojaee-Moradie, Fariba ; Charles-Edwards, Geoff ; Peacock, Janet L. ; Margot Umpleby, A. ; Amiel, Stephanie A. ; Goff, Louise M. / Differences in the link between insulin sensitivity and ectopic fat in men of Black African and White European ethnicity. In: European Journal of Endocrinology. 2020 ; Vol. 182, No. 1. pp. 91-101.

Bibtex Download

@article{c2c4482a0b05497fa6ffcf31ce885762,
title = "Differences in the link between insulin sensitivity and ectopic fat in men of Black African and White European ethnicity",
abstract = "Objectives: In men of black west African (BAM) and white European (WEM) ethnicity, we aimed to (1) compare adipose tissue, peripheral and hepatic insulin sensitivity and (2) investigate associations between ectopic fat and insulin sensitivity by ethnicity. Design and methods: In overweight BAM (n = 21) and WEM (n = 23) with normal glucose tolerance, we performed a two-step hyperinsulinaemic-euglycaemic clamp with infusion of [6,6 2H2]-glucose and [2H5]-glycerol to measure whole body, peripheral, hepatic and adipose tissue insulin sensitivity (lipolysis). Visceral adipose tissue (VAT), intrahepatic lipids (IHL) and intramyocellular (IMCL) lipids were measured using MRI and spectroscopy. Associations between insulin sensitivity and ectopic fat were assessed using Pearson's correlation coefficient by ethnicity and regression analysis. Results: There were no ethnic differences in whole body or tissue-specific insulin sensitivity (all P > 0.05). Suppression of lipolysis was inversely associated with VAT and IHL in WEM but not BAM (VAT: WEM r = −0.68, P < 0.01; BAM r = 0.07, P = 0.79. IHL: WEM r = −0.52, P = 0.01; BAM r = −0.12, P = 0.63). IMCL was inversely associated with skeletal muscle insulin sensitivity in WEM but not BAM (WEM r = −0.56, P < 0.01; BAM r = −0.09, P = 0.75) and IHL was inversely associated with hepatic insulin sensitivity in WEM but not BAM (WEM r = −0.53, P = 0.02; BAM r = −0.13, P = 0.62). Conclusions: Ectopic fat deposition may play a lesser role in reducing insulin sensitivity in men of black African ethnicity and may not be driven by lipolysis. Resistance to storing VAT, IHL and IMCL may enable men of black African ethnicity to maintain comparable insulin sensitivity to white Europeans.",
author = "Oluwatoyosi Bello and Meera Ladwa and Olah Hakim and Chinmay Marathe and Fariba Shojaee-Moradie and Geoff Charles-Edwards and Peacock, {Janet L.} and {Margot Umpleby}, A. and Amiel, {Stephanie A.} and Goff, {Louise M.}",
year = "2020",
month = "1",
day = "1",
doi = "10.1530/EJE-19-0636",
language = "English",
volume = "182",
pages = "91--101",
journal = "European journal of endocrinology / European Federation of Endocrine Societies",
issn = "0804-4643",
number = "1",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Differences in the link between insulin sensitivity and ectopic fat in men of Black African and White European ethnicity

AU - Bello, Oluwatoyosi

AU - Ladwa, Meera

AU - Hakim, Olah

AU - Marathe, Chinmay

AU - Shojaee-Moradie, Fariba

AU - Charles-Edwards, Geoff

AU - Peacock, Janet L.

AU - Margot Umpleby, A.

AU - Amiel, Stephanie A.

AU - Goff, Louise M.

PY - 2020/1/1

Y1 - 2020/1/1

N2 - Objectives: In men of black west African (BAM) and white European (WEM) ethnicity, we aimed to (1) compare adipose tissue, peripheral and hepatic insulin sensitivity and (2) investigate associations between ectopic fat and insulin sensitivity by ethnicity. Design and methods: In overweight BAM (n = 21) and WEM (n = 23) with normal glucose tolerance, we performed a two-step hyperinsulinaemic-euglycaemic clamp with infusion of [6,6 2H2]-glucose and [2H5]-glycerol to measure whole body, peripheral, hepatic and adipose tissue insulin sensitivity (lipolysis). Visceral adipose tissue (VAT), intrahepatic lipids (IHL) and intramyocellular (IMCL) lipids were measured using MRI and spectroscopy. Associations between insulin sensitivity and ectopic fat were assessed using Pearson's correlation coefficient by ethnicity and regression analysis. Results: There were no ethnic differences in whole body or tissue-specific insulin sensitivity (all P > 0.05). Suppression of lipolysis was inversely associated with VAT and IHL in WEM but not BAM (VAT: WEM r = −0.68, P < 0.01; BAM r = 0.07, P = 0.79. IHL: WEM r = −0.52, P = 0.01; BAM r = −0.12, P = 0.63). IMCL was inversely associated with skeletal muscle insulin sensitivity in WEM but not BAM (WEM r = −0.56, P < 0.01; BAM r = −0.09, P = 0.75) and IHL was inversely associated with hepatic insulin sensitivity in WEM but not BAM (WEM r = −0.53, P = 0.02; BAM r = −0.13, P = 0.62). Conclusions: Ectopic fat deposition may play a lesser role in reducing insulin sensitivity in men of black African ethnicity and may not be driven by lipolysis. Resistance to storing VAT, IHL and IMCL may enable men of black African ethnicity to maintain comparable insulin sensitivity to white Europeans.

AB - Objectives: In men of black west African (BAM) and white European (WEM) ethnicity, we aimed to (1) compare adipose tissue, peripheral and hepatic insulin sensitivity and (2) investigate associations between ectopic fat and insulin sensitivity by ethnicity. Design and methods: In overweight BAM (n = 21) and WEM (n = 23) with normal glucose tolerance, we performed a two-step hyperinsulinaemic-euglycaemic clamp with infusion of [6,6 2H2]-glucose and [2H5]-glycerol to measure whole body, peripheral, hepatic and adipose tissue insulin sensitivity (lipolysis). Visceral adipose tissue (VAT), intrahepatic lipids (IHL) and intramyocellular (IMCL) lipids were measured using MRI and spectroscopy. Associations between insulin sensitivity and ectopic fat were assessed using Pearson's correlation coefficient by ethnicity and regression analysis. Results: There were no ethnic differences in whole body or tissue-specific insulin sensitivity (all P > 0.05). Suppression of lipolysis was inversely associated with VAT and IHL in WEM but not BAM (VAT: WEM r = −0.68, P < 0.01; BAM r = 0.07, P = 0.79. IHL: WEM r = −0.52, P = 0.01; BAM r = −0.12, P = 0.63). IMCL was inversely associated with skeletal muscle insulin sensitivity in WEM but not BAM (WEM r = −0.56, P < 0.01; BAM r = −0.09, P = 0.75) and IHL was inversely associated with hepatic insulin sensitivity in WEM but not BAM (WEM r = −0.53, P = 0.02; BAM r = −0.13, P = 0.62). Conclusions: Ectopic fat deposition may play a lesser role in reducing insulin sensitivity in men of black African ethnicity and may not be driven by lipolysis. Resistance to storing VAT, IHL and IMCL may enable men of black African ethnicity to maintain comparable insulin sensitivity to white Europeans.

UR - http://www.scopus.com/inward/record.url?scp=85078078892&partnerID=8YFLogxK

U2 - 10.1530/EJE-19-0636

DO - 10.1530/EJE-19-0636

M3 - Article

C2 - 31721724

AN - SCOPUS:85078078892

VL - 182

SP - 91

EP - 101

JO - European journal of endocrinology / European Federation of Endocrine Societies

JF - European journal of endocrinology / European Federation of Endocrine Societies

SN - 0804-4643

IS - 1

ER -

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