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Différenciation neurale des cellules souches embryonnaires

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Différenciation neurale des cellules souches embryonnaires. / Cazillis, Michèle; Lelièvre, Vincent; Gressens, Pierre.

In: M S-MEDECINE SCIENCES, Vol. 21, No. 5, 05.2005, p. 484-490.

Research output: Contribution to journalArticle

Harvard

Cazillis, M, Lelièvre, V & Gressens, P 2005, 'Différenciation neurale des cellules souches embryonnaires', M S-MEDECINE SCIENCES, vol. 21, no. 5, pp. 484-490. https://doi.org/10.1051/medsci/2005215484

APA

Cazillis, M., Lelièvre, V., & Gressens, P. (2005). Différenciation neurale des cellules souches embryonnaires. M S-MEDECINE SCIENCES, 21(5), 484-490. https://doi.org/10.1051/medsci/2005215484

Vancouver

Cazillis M, Lelièvre V, Gressens P. Différenciation neurale des cellules souches embryonnaires. M S-MEDECINE SCIENCES. 2005 May;21(5):484-490. https://doi.org/10.1051/medsci/2005215484

Author

Cazillis, Michèle ; Lelièvre, Vincent ; Gressens, Pierre. / Différenciation neurale des cellules souches embryonnaires. In: M S-MEDECINE SCIENCES. 2005 ; Vol. 21, No. 5. pp. 484-490.

Bibtex Download

@article{e0c65775509449b8ab7a82045991e1e5,
title = "Diff{\'e}renciation neurale des cellules souches embryonnaires",
abstract = "Pluripotent murine embryonic stem (ES) cells can differentiate into all cell types both in vivo and in vitro. Based on their capability to proliferate and differentiate, these ES cells appear as a very promising tool for cell therapy. The understanding of the molecular mechanisms underlying the neural differentiation of the ES cells is a pre-requisite for selecting adequately the cells and conditions which will be able to correctly repair damaged brain and restore altered cognitive functions. Different methods allow obtaining neural cells from ES cells. Most of the techniques differentiate ES cells by treating embryoid bodies in order to keep an embryonic organization. More recent techniques, based on conditioned media, induce a direct differentiation of ES cells into neural cells, without going through the step of embryonic bodies. Beyond the fact that these techniques allow obtaining large numbers of neural precursors and more differentiated neural cells, these approaches also provide valuable information on the process of differentiation of ES cells into neural cells. Indeed, sequential studies of this process of differentiation have revealed that globally ES cells differentiating into neural cells in vitro recapitulate the molecular events governing the in vivo differentiation of neural cells. Altogether these data suggest that murine ES cells remain a highly valuable tool to obtain large amounts of precursor and differentiated neural cells as well as to get a better understanding of the mechanisms of neural differentiation, prior to a potential move towards the use of human ES cells in therapy.",
keywords = "Animals, Cell Differentiation, Ectoderm, Mice, Neurons, Pluripotent Stem Cells",
author = "Mich{\`e}le Cazillis and Vincent Leli{\`e}vre and Pierre Gressens",
year = "2005",
month = "5",
doi = "10.1051/medsci/2005215484",
language = "French",
volume = "21",
pages = "484--490",
journal = "M S-MEDECINE SCIENCES",
issn = "0767-0974",
publisher = "Editions EDK",
number = "5",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Différenciation neurale des cellules souches embryonnaires

AU - Cazillis, Michèle

AU - Lelièvre, Vincent

AU - Gressens, Pierre

PY - 2005/5

Y1 - 2005/5

N2 - Pluripotent murine embryonic stem (ES) cells can differentiate into all cell types both in vivo and in vitro. Based on their capability to proliferate and differentiate, these ES cells appear as a very promising tool for cell therapy. The understanding of the molecular mechanisms underlying the neural differentiation of the ES cells is a pre-requisite for selecting adequately the cells and conditions which will be able to correctly repair damaged brain and restore altered cognitive functions. Different methods allow obtaining neural cells from ES cells. Most of the techniques differentiate ES cells by treating embryoid bodies in order to keep an embryonic organization. More recent techniques, based on conditioned media, induce a direct differentiation of ES cells into neural cells, without going through the step of embryonic bodies. Beyond the fact that these techniques allow obtaining large numbers of neural precursors and more differentiated neural cells, these approaches also provide valuable information on the process of differentiation of ES cells into neural cells. Indeed, sequential studies of this process of differentiation have revealed that globally ES cells differentiating into neural cells in vitro recapitulate the molecular events governing the in vivo differentiation of neural cells. Altogether these data suggest that murine ES cells remain a highly valuable tool to obtain large amounts of precursor and differentiated neural cells as well as to get a better understanding of the mechanisms of neural differentiation, prior to a potential move towards the use of human ES cells in therapy.

AB - Pluripotent murine embryonic stem (ES) cells can differentiate into all cell types both in vivo and in vitro. Based on their capability to proliferate and differentiate, these ES cells appear as a very promising tool for cell therapy. The understanding of the molecular mechanisms underlying the neural differentiation of the ES cells is a pre-requisite for selecting adequately the cells and conditions which will be able to correctly repair damaged brain and restore altered cognitive functions. Different methods allow obtaining neural cells from ES cells. Most of the techniques differentiate ES cells by treating embryoid bodies in order to keep an embryonic organization. More recent techniques, based on conditioned media, induce a direct differentiation of ES cells into neural cells, without going through the step of embryonic bodies. Beyond the fact that these techniques allow obtaining large numbers of neural precursors and more differentiated neural cells, these approaches also provide valuable information on the process of differentiation of ES cells into neural cells. Indeed, sequential studies of this process of differentiation have revealed that globally ES cells differentiating into neural cells in vitro recapitulate the molecular events governing the in vivo differentiation of neural cells. Altogether these data suggest that murine ES cells remain a highly valuable tool to obtain large amounts of precursor and differentiated neural cells as well as to get a better understanding of the mechanisms of neural differentiation, prior to a potential move towards the use of human ES cells in therapy.

KW - Animals

KW - Cell Differentiation

KW - Ectoderm

KW - Mice

KW - Neurons

KW - Pluripotent Stem Cells

U2 - 10.1051/medsci/2005215484

DO - 10.1051/medsci/2005215484

M3 - Article

C2 - 15885197

VL - 21

SP - 484

EP - 490

JO - M S-MEDECINE SCIENCES

JF - M S-MEDECINE SCIENCES

SN - 0767-0974

IS - 5

ER -

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