Differential associations of IL-4 with hippocampal subfields in mild cognitive impairment and Alzheimer's disease

TY - JOUR

T1 - Differential associations of IL-4 with hippocampal subfields in mild cognitive impairment and Alzheimer's disease

AU - AddNeuroMed Project

AU - Boccardi, Virginia

AU - Westman, Eric

AU - Pelini, Luca

AU - Lindberg, Olof

AU - Muehlboeck, J. Sebastian

AU - Simmons, Andrew

AU - Tarducci, Roberto

AU - Floridi, Piero

AU - Chiarini, Pietro

AU - Soininen, Hilkka

AU - Kloszewska, Iwona

AU - Tsolaki, Magda

AU - Vellas, Bruno

AU - Spenger, Christian

AU - Wahlund, Lars Olof

AU - Lovestone, Simon

AU - Mecocci, Patrizia

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Background/Aims: We aimed to assess the association between in volumetric measures of hippocampal sub-regions - in healthy older controls (HC), subjects with mild cognitive impairment (MCI) and AD-with circulating levels of IL-4. Methods: From AddNeuroMed Project 113 HC, 101 stable MCI (sMCI), 22 converter MCI (cMCI) and 119 AD were included. Hippocampal subfield volumes were analyzed using Freesurfer 6.0.0 on high-resolution sagittal 3D-T1W MP-RAGE acquisitions. Plasmatic IL-4 was measured using ELISA assay. Results: IL-4 was found to be (a) positively associate with left subiculum volume (β = 0.226, p = 0.037) in sMCI and (b) negatively associate with left subiculum volume (β = -0.253, p = 0.011) and left presubiculum volume (β = -0.257, p = 0.011) in AD. Conclusion: Our results indicate a potential neuroprotective effect of IL-4 on the areas of the hippocampus more vulnerable to aging and neurodegeneration.

AB - Background/Aims: We aimed to assess the association between in volumetric measures of hippocampal sub-regions - in healthy older controls (HC), subjects with mild cognitive impairment (MCI) and AD-with circulating levels of IL-4. Methods: From AddNeuroMed Project 113 HC, 101 stable MCI (sMCI), 22 converter MCI (cMCI) and 119 AD were included. Hippocampal subfield volumes were analyzed using Freesurfer 6.0.0 on high-resolution sagittal 3D-T1W MP-RAGE acquisitions. Plasmatic IL-4 was measured using ELISA assay. Results: IL-4 was found to be (a) positively associate with left subiculum volume (β = 0.226, p = 0.037) in sMCI and (b) negatively associate with left subiculum volume (β = -0.253, p = 0.011) and left presubiculum volume (β = -0.257, p = 0.011) in AD. Conclusion: Our results indicate a potential neuroprotective effect of IL-4 on the areas of the hippocampus more vulnerable to aging and neurodegeneration.

KW - Aging

KW - Alzheimer's disease

KW - Inflammation

KW - Inflammatory markers

KW - Mild cognitive impairment

UR - http://www.scopus.com/inward/record.url?scp=85064269485&partnerID=8YFLogxK

U2 - 10.3389/fnagi.2018.00439

DO - 10.3389/fnagi.2018.00439

M3 - Article

AN - SCOPUS:85064269485

SN - 1663-4365

VL - 11

JO - Frontiers in Aging Neuroscience

JF - Frontiers in Aging Neuroscience

IS - JAN

M1 - 439

ER -