TY - JOUR
T1 - Differential block by troglitazone and rosiglitazone of glibenclamide-sensitive K+ current in rat aorta myocytes
AU - Mishra, S K
AU - Aaronson, P I
PY - 1999/12/10
Y1 - 1999/12/10
N2 - Thiazolidinediones are insulin-sensitising agents effective in controlling type II diabetes. These compounds also cause vasodilation. We evaluated the effects of the thiazolidinediones troglitazone and rosiglitazone on the glibenclamide-sensitive K+ current in freshly isolated rat aorta myocytes. Troglitazone inhibited this current in a concentration-dependent manner (IC50 similar to 1 mu M) Rosiglitazone had a similar, but much less potent (IC50 similar to 20 mu M) action. Block of the glibenclamide-sensitive K+ channels, in particular by troglitazone, may potentially affect the response of arteries to hypoxia and to certain endogenous and exogenous vasodilators. (C) 1999 Elsevier Science B.V. All rights reserved.
AB - Thiazolidinediones are insulin-sensitising agents effective in controlling type II diabetes. These compounds also cause vasodilation. We evaluated the effects of the thiazolidinediones troglitazone and rosiglitazone on the glibenclamide-sensitive K+ current in freshly isolated rat aorta myocytes. Troglitazone inhibited this current in a concentration-dependent manner (IC50 similar to 1 mu M) Rosiglitazone had a similar, but much less potent (IC50 similar to 20 mu M) action. Block of the glibenclamide-sensitive K+ channels, in particular by troglitazone, may potentially affect the response of arteries to hypoxia and to certain endogenous and exogenous vasodilators. (C) 1999 Elsevier Science B.V. All rights reserved.
UR - http://www.scopus.com/inward/record.url?scp=0033458090&partnerID=8YFLogxK
U2 - 10.1016/S0014-2999(99)00713-X
DO - 10.1016/S0014-2999(99)00713-X
M3 - Article
VL - 386
SP - 121
EP - 125
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
IS - 1
ER -
