Abstract
Our objective was to investigate whether the presence of Glu298Asp polymorphism in the endothelial NO synthase (eNOS) gene differentially affects the postprandial blood pressure response to dietary nitrate-rich beetroot bread. A randomised, single-blind, controlled, crossover acute pilot study was performed in 14 healthy men (mean age: 34±9 years) who were retrospectively genotyped for Glu298Asp polymorphism (7GG; T carriers 7). Volunteers were randomised to receive 200 g beetroot-enriched bread (1.1 mmol nitrate) or control bread (no beetroot; 0.01 mmol nitrate) on two separate occasions 10 days apart. Baseline and incremental area under the curve of blood pressure and NOx (nitrate/nitrite) were measured for a 6-h postprandial period. A treatment × genotype interaction was observed for diastolic blood pressure (P<0.02), which was significantly lower in T carriers (P<0.01) after consumption of beetroot bread compared with control bread. No significant differences were observed in the GG group. The beneficial diastolic blood pressure reduction was observed only in the T carriers of the Glu298Asp polymorphism in the eNOS gene after consumption of nitrate-rich beetroot bread. These data require confirmation in a larger population group.
| Original language | English |
|---|---|
| Pages (from-to) | 726-30 |
| Number of pages | 5 |
| Journal | Journal of Human Hypertension |
| Volume | 28 |
| Issue number | 12 |
| DOIs | |
| Publication status | Published - Dec 2014 |
Keywords
- Adolescent
- Adult
- Blood Pressure
- Bread
- Humans
- Male
- Middle Aged
- Nitrates
- Nitric Oxide Synthase Type III
- Pilot Projects
- Polymorphism, Single Nucleotide
- Vegetables