TY - JOUR
T1 - Differential predictors for alcohol use in adolescents as a function of familial risk
AU - IMAGEN Consortium
AU - Tschorn, Mira
AU - Lorenz, Robert C.
AU - O’Reilly, Paul F.
AU - Reichenberg, Abraham
AU - Banaschewski, Tobias
AU - Bokde, Arun L.W.
AU - Quinlan, Erin B.
AU - Desrivières, Sylvane
AU - Flor, Herta
AU - Grigis, Antoine
AU - Garavan, Hugh
AU - Gowland, Penny
AU - Ittermann, Bernd
AU - Martinot, Jean Luc
AU - Artiges, Eric
AU - Nees, Frauke
AU - Papadopoulos Orfanos, Dimitri
AU - Poustka, Luise
AU - Millenet, Sabina
AU - Fröhner, Juliane H.
AU - Smolka, Michael N.
AU - Walter, Henrik
AU - Whelan, Robert
AU - Schumann, Gunter
AU - Heinz, Andreas
AU - Rapp, Michael A.
AU - Robbins, Trevor
AU - Dalley, Jeffrey
AU - Subramaniam, Naresh
AU - Theobald, David
AU - Mann, Karl
AU - Bach, Christiane
AU - Struve, Maren
AU - Banaschewski, Tobias
AU - Flor, Herta
AU - Rietschel, Marcella
AU - Reuter, Jan
AU - Cattrell, Anna
AU - Jia, Tianye
AU - Desrivières, Sylvane
AU - Werts, Helen
AU - Topper, Lauren
AU - Mallik, Catherine
AU - Ruggeri, Barbara
AU - Nymberg, Charlotte
AU - Barker, Gareth
AU - Conrod, Patricia J.
AU - Loth, Eva
AU - Macare, Christine
AU - Newman, Craig
N1 - Publisher Copyright:
© 2021, The Author(s).
Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2021/6
Y1 - 2021/6
N2 - Traditional models of future alcohol use in adolescents have used variable-centered approaches, predicting alcohol use from a set of variables across entire samples or populations. Following the proposition that predictive factors may vary in adolescents as a function of family history, we used a two-pronged approach by first defining clusters of familial risk, followed by prediction analyses within each cluster. Thus, for the first time in adolescents, we tested whether adolescents with a family history of drug abuse exhibit a set of predictors different from adolescents without a family history. We apply this approach to a genetic risk score and individual differences in personality, cognition, behavior (risk-taking and discounting) substance use behavior at age 14, life events, and functional brain imaging, to predict scores on the alcohol use disorders identification test (AUDIT) at age 14 and 16 in a sample of adolescents (N = 1659 at baseline, N = 1327 at follow-up) from the IMAGEN cohort, a longitudinal community-based cohort of adolescents. In the absence of familial risk (n = 616), individual differences in baseline drinking, personality measures (extraversion, negative thinking), discounting behaviors, life events, and ventral striatal activation during reward anticipation were significantly associated with future AUDIT scores, while the overall model explained 22% of the variance in future AUDIT. In the presence of familial risk (n = 711), drinking behavior at age 14, personality measures (extraversion, impulsivity), behavioral risk-taking, and life events were significantly associated with future AUDIT scores, explaining 20.1% of the overall variance. Results suggest that individual differences in personality, cognition, life events, brain function, and drinking behavior contribute differentially to the prediction of future alcohol misuse. This approach may inform more individualized preventive interventions.
AB - Traditional models of future alcohol use in adolescents have used variable-centered approaches, predicting alcohol use from a set of variables across entire samples or populations. Following the proposition that predictive factors may vary in adolescents as a function of family history, we used a two-pronged approach by first defining clusters of familial risk, followed by prediction analyses within each cluster. Thus, for the first time in adolescents, we tested whether adolescents with a family history of drug abuse exhibit a set of predictors different from adolescents without a family history. We apply this approach to a genetic risk score and individual differences in personality, cognition, behavior (risk-taking and discounting) substance use behavior at age 14, life events, and functional brain imaging, to predict scores on the alcohol use disorders identification test (AUDIT) at age 14 and 16 in a sample of adolescents (N = 1659 at baseline, N = 1327 at follow-up) from the IMAGEN cohort, a longitudinal community-based cohort of adolescents. In the absence of familial risk (n = 616), individual differences in baseline drinking, personality measures (extraversion, negative thinking), discounting behaviors, life events, and ventral striatal activation during reward anticipation were significantly associated with future AUDIT scores, while the overall model explained 22% of the variance in future AUDIT. In the presence of familial risk (n = 711), drinking behavior at age 14, personality measures (extraversion, impulsivity), behavioral risk-taking, and life events were significantly associated with future AUDIT scores, explaining 20.1% of the overall variance. Results suggest that individual differences in personality, cognition, life events, brain function, and drinking behavior contribute differentially to the prediction of future alcohol misuse. This approach may inform more individualized preventive interventions.
UR - http://www.scopus.com/inward/record.url?scp=85102197494&partnerID=8YFLogxK
U2 - 10.1038/s41398-021-01260-7
DO - 10.1038/s41398-021-01260-7
M3 - Article
AN - SCOPUS:85102197494
SN - 2158-3188
VL - 11
JO - Translational psychiatry
JF - Translational psychiatry
IS - 1
M1 - 157
ER -