Differential Survival characteristics of sarcomatoid subtype biphasic pleural mesothelioma

Leanne Harling, Styliani Maria Kolokotroni, Arjun Nair, Jeremy Smelt, Juliet King, Tom Routledge, James Spicer, Wen Ng, Andrea Bille

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7 Citations (Scopus)
163 Downloads (Pure)

Abstract

Background Biphasic mesothelioma (BPM) accounts for approximately 10% of all pleural mesothelioma. Our aim was to assess the clinical, radiological and pathological factors impacting survival in BPM and to better identify patients most likely to benefit from active treatment. Methods Ten-year retrospective review of 214 biopsy-proven BPM cases with minimum 2-year follow-up. Patients with insufficient tissue for analysis were excluded (n=96). Clinical and pathological factors were evaluated along with radiological assessment of pleural thickness. Survival was measured from time of diagnosis. Uni- and multi-variable predictors of survival were evaluated. Results 118 patients were included. 28 underwent pleurectomy/decortication (P/D), with 27 receiving additional modalities. 90 underwent chemotherapy (n=18) or radiotherapy alone (n=9), 63 received combination therapy, and 27 received best supportive care (BSC). Median overall survival was 11.2 months (0.3–36.2). At univariable analysis, P/D (p=0.0061), radiotherapy (RT; p
Original languageEnglish
JournalAnnals of Thoracic Surgery
Early online date30 Oct 2018
DOIs
Publication statusE-pub ahead of print - 30 Oct 2018

Keywords

  • Biphasic Mesothelioma
  • Histopathology
  • Survival
  • Pleurectomy/decortication
  • radiotherapy

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