Diffusion-weighted magnetic resonance imaging detects early neuropathology following four vessel occlusion ischemia in the rat

TY - JOUR

T1 - Diffusion-weighted magnetic resonance imaging detects early neuropathology following four vessel occlusion ischemia in the rat

AU - Gregory, L J

AU - O'Neill, M J

AU - Nunn, J A

AU - Gray, J A

AU - Williams, S C R

PY - 2001/9

Y1 - 2001/9

N2 - Early neuropathology following a prolonged duration of four-vessel occlusion (4 VO) ischemia in the rat was charted using magnetic resonance imaging [MRI). Animals received either 30 minutes of 4 VO (N = 6) or sham operation (N = S) prior to in vivo assessment. Proton density and T-2 and combined T-2/diffusion-weighted (T-2/ DW) MRI mere performed at 6, 24, and 72 hours postocclusion. T-2/DW imaging was the most effective sequence for delineating between injured and intact tissues, indicating neuropathology in the dorsolateral striatum at 24 hours and in the CA1/CA2 subfields of the hippocampus at 72 hours following ischemia. Apparent diffusion coeficient values were significantly reduced in the striatum (P = 0.03) and hippocampus (P = 0.005) at 24 and 72 hours, respectively. This is the first report, to our knowledge, of T-2/DW imaging detecting lesions following 4 VO is accord with the known temporal evolution of ischemic brain damage. J. Magn. Reson. Imaging 2001; 14:207-214. (C) 2001 Wiley-Liss, Inc.

AB - Early neuropathology following a prolonged duration of four-vessel occlusion (4 VO) ischemia in the rat was charted using magnetic resonance imaging [MRI). Animals received either 30 minutes of 4 VO (N = 6) or sham operation (N = S) prior to in vivo assessment. Proton density and T-2 and combined T-2/diffusion-weighted (T-2/ DW) MRI mere performed at 6, 24, and 72 hours postocclusion. T-2/DW imaging was the most effective sequence for delineating between injured and intact tissues, indicating neuropathology in the dorsolateral striatum at 24 hours and in the CA1/CA2 subfields of the hippocampus at 72 hours following ischemia. Apparent diffusion coeficient values were significantly reduced in the striatum (P = 0.03) and hippocampus (P = 0.005) at 24 and 72 hours, respectively. This is the first report, to our knowledge, of T-2/DW imaging detecting lesions following 4 VO is accord with the known temporal evolution of ischemic brain damage. J. Magn. Reson. Imaging 2001; 14:207-214. (C) 2001 Wiley-Liss, Inc.

M3 - Article

SN - 1053-1807

VL - 14

SP - 207

EP - 214

JO - Journal of Magnetic Resonance Imaging

JF - Journal of Magnetic Resonance Imaging

IS - 3

ER -