Diflunisal-adjoined cobalt(iii)-polypyridyl complexes as anti-cancer stem cell agents complexes as anti-cancer stem cell agents†

David O. Abe, Arvin Eskandari, Kogularamanan Suntharalingam*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)

Abstract

We report a novel series of cobalt(iii)-polypridyl complexes, 4-6, that can selectively release diflunisal, a nonsteroidal anti-inflammatory drug, under reducing conditions. Remarkably, the 1,10-phenanthroline-bearing complex 5 displays selective potency towards hard-to-kill cancer stem cells (CSCs) (IC50 = 2.1 ± 0.1 μM) over bulk cancer (IC50 = 3.9 ± 0.2 μM) and normal cells (IC50 = 21.2 ± 1.3 μM). This complex induces CSC apoptosis by DNA damage and cyclooxygenase-2 inhibition.

Original languageEnglish
Pages (from-to)13761-13765
Number of pages5
JournalDalton Transactions
Volume47
Issue number39
DOIs
Publication statusPublished - 10 Sept 2018

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