Digital physical activity intervention via the Kidney BEAM platform in patients with polycystic kidney disease: a randomized controlled trial

TY - JOUR

T1 - Digital physical activity intervention via the Kidney BEAM platform in patients with polycystic kidney disease

T2 - a randomized controlled trial

AU - Briggs, Juliet

AU - Ralston, Elizabeth

AU - Wilkinson, Thomas J

AU - Walklin, Christy

AU - Mangahis, Emmanuel

AU - Young, Hannah M.L

AU - Castle, Ellen. M

AU - Billany, Roseanne E

AU - Asgari, Elham

AU - Bhandari, Sunil

AU - Bramham, Kate

AU - Burton, James O

AU - Campbell, Jackie

AU - Chilcot, Joseph

AU - Deelchand, Vashist

AU - Hamilton, Alexander

AU - Jesky, Mark

AU - Kalra, Philip A

AU - McCafferty, Kieran

AU - Nixon, Andrew C

AU - Saynor, Zoe L

AU - Taal, Maarten W

AU - Tollitt, James

AU - Wheeler, David. C

AU - Macdonald, Jamie

AU - Greenwood, Sharlene A.

N1 - Publisher Copyright: © The Author(s) 2025. Published by Oxford University Press on behalf of the ERA.

PY - 2025/3/1

Y1 - 2025/3/1

N2 - Background. In people living with polycystic kidney disease (PKD), physical inactivity may contribute to poor health-related quality of life (HRQoL). To date, no research has elucidated the impact of a PKD-specific physical activity programme on HRQoL and physical health. This substudy of the Kidney BEAM Trial evaluated the impact of a PKD-specific 12-week educational and physical activity digital health intervention for people living with PKD. Methods. This study was a mixed-methods, single-blind, randomized waitlist-controlled trial. Sixty adults with a diagnosis of PKD were randomized 1:1 to the intervention or a waitlist control group. Primary outcome was difference in the Kidney Disease QoL Short Form 1.3 Mental Component Summary (KDQoL-SF1.3 MCS) between baseline and 12 weeks. Six participants completed individualized semi-structured interviews. Results. All 60 individuals (mean 53 years, 37% male) were included in the intention-to-treat analysis. At 12 weeks, there was a significant difference in mean adjusted change in KDQoL MCS score between the intervention group and waitlist control [4.2 (95% confidence interval 1.0–7.4) arbitrary units, P = .012]. Significant between-group differences in KDQoL subscales—burden of kidney disease (P = .034), emotional wellbeing (P = .001) and energy/fatigue (P = .001)—were also achieved. There was no significant between-group difference in KDQoL PCS scores (P = .505). Per-protocol analyses revealed significant between group differences in the PAM-13 patient activation score (P = .010) and body mass (P = .027). Mixed-methods analyses revealed key influences of the programme, including opportunities for peer support and to build on new skills and knowledge, as well as the empowerment and self-management. Conclusion. A PKD-specific digital health educational and physical activity intervention is acceptable and has the potential to improve HRQoL. Further research is needed to better understand how specific education and lifestyle management may help to support self-management behaviour.

AB - Background. In people living with polycystic kidney disease (PKD), physical inactivity may contribute to poor health-related quality of life (HRQoL). To date, no research has elucidated the impact of a PKD-specific physical activity programme on HRQoL and physical health. This substudy of the Kidney BEAM Trial evaluated the impact of a PKD-specific 12-week educational and physical activity digital health intervention for people living with PKD. Methods. This study was a mixed-methods, single-blind, randomized waitlist-controlled trial. Sixty adults with a diagnosis of PKD were randomized 1:1 to the intervention or a waitlist control group. Primary outcome was difference in the Kidney Disease QoL Short Form 1.3 Mental Component Summary (KDQoL-SF1.3 MCS) between baseline and 12 weeks. Six participants completed individualized semi-structured interviews. Results. All 60 individuals (mean 53 years, 37% male) were included in the intention-to-treat analysis. At 12 weeks, there was a significant difference in mean adjusted change in KDQoL MCS score between the intervention group and waitlist control [4.2 (95% confidence interval 1.0–7.4) arbitrary units, P = .012]. Significant between-group differences in KDQoL subscales—burden of kidney disease (P = .034), emotional wellbeing (P = .001) and energy/fatigue (P = .001)—were also achieved. There was no significant between-group difference in KDQoL PCS scores (P = .505). Per-protocol analyses revealed significant between group differences in the PAM-13 patient activation score (P = .010) and body mass (P = .027). Mixed-methods analyses revealed key influences of the programme, including opportunities for peer support and to build on new skills and knowledge, as well as the empowerment and self-management. Conclusion. A PKD-specific digital health educational and physical activity intervention is acceptable and has the potential to improve HRQoL. Further research is needed to better understand how specific education and lifestyle management may help to support self-management behaviour.

UR - http://www.scopus.com/inward/record.url?scp=105000348951&partnerID=8YFLogxK

U2 - 10.1093/ckj/sfaf041

DO - 10.1093/ckj/sfaf041

M3 - Article

SN - 2048-8505

VL - 18

JO - Clinical Kidney Journal

JF - Clinical Kidney Journal

IS - 3

M1 - sfaf041

ER -