Dioscorealides and dioscoreanone, novel cytotoxic naphthofuranoxepins, and 1,4-phenanthraquinone from Dioscorea membranacea Pierre

A Itharat; A Plubrukarn; P Kongsaeree; T Bui; N Keawpradub; P J Houghton

doi:10.1021/ol034926y

Dioscorealides and dioscoreanone, novel cytotoxic naphthofuranoxepins, and 1,4-phenanthraquinone from Dioscorea membranacea Pierre

A Itharat, A Plubrukarn, P Kongsaeree, T Bui, N Keawpradub, P J Houghton

Research output: Contribution to journal › Article › peer-review

31 Citations (Scopus)

Abstract

graphics Commonly used among ingredients in Thai traditional anticancer preparations, the rhizome of Dioscorea membranacea Pierre was found potently cytotoxic and possibly contributed to such a therapeutic effect. Bioassay-guided isolation resulted in two novel cytotoxic naphthofuranoxepins, dioscorealides A (1) and B (2), and a new 1,4-phenanthraquinone, dioscoreanone (3). The structure determination, achieved mainly by means of NMR and CD spectral and X-ray crystallographic analyses, and cytotoxicity are discussed here.

Original language	English
Pages (from-to)	2879 - 2882
Number of pages	4
Journal	ORGANIC LETTERS
Volume	5
Issue number	16
DOIs	https://doi.org/10.1021/ol034926y
Publication status	Published - 7 Aug 2003

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title = "Dioscorealides and dioscoreanone, novel cytotoxic naphthofuranoxepins, and 1,4-phenanthraquinone from Dioscorea membranacea Pierre",

abstract = "graphics Commonly used among ingredients in Thai traditional anticancer preparations, the rhizome of Dioscorea membranacea Pierre was found potently cytotoxic and possibly contributed to such a therapeutic effect. Bioassay-guided isolation resulted in two novel cytotoxic naphthofuranoxepins, dioscorealides A (1) and B (2), and a new 1,4-phenanthraquinone, dioscoreanone (3). The structure determination, achieved mainly by means of NMR and CD spectral and X-ray crystallographic analyses, and cytotoxicity are discussed here.",

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T1 - Dioscorealides and dioscoreanone, novel cytotoxic naphthofuranoxepins, and 1,4-phenanthraquinone from Dioscorea membranacea Pierre

AU - Itharat, A

AU - Plubrukarn, A

AU - Kongsaeree, P

AU - Bui, T

AU - Keawpradub, N

AU - Houghton, P J

PY - 2003/8/7

Y1 - 2003/8/7

N2 - graphics Commonly used among ingredients in Thai traditional anticancer preparations, the rhizome of Dioscorea membranacea Pierre was found potently cytotoxic and possibly contributed to such a therapeutic effect. Bioassay-guided isolation resulted in two novel cytotoxic naphthofuranoxepins, dioscorealides A (1) and B (2), and a new 1,4-phenanthraquinone, dioscoreanone (3). The structure determination, achieved mainly by means of NMR and CD spectral and X-ray crystallographic analyses, and cytotoxicity are discussed here.

AB - graphics Commonly used among ingredients in Thai traditional anticancer preparations, the rhizome of Dioscorea membranacea Pierre was found potently cytotoxic and possibly contributed to such a therapeutic effect. Bioassay-guided isolation resulted in two novel cytotoxic naphthofuranoxepins, dioscorealides A (1) and B (2), and a new 1,4-phenanthraquinone, dioscoreanone (3). The structure determination, achieved mainly by means of NMR and CD spectral and X-ray crystallographic analyses, and cytotoxicity are discussed here.

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U2 - 10.1021/ol034926y

DO - 10.1021/ol034926y

M3 - Article

SN - 1523-7052

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SP - 2879

EP - 2882

JO - ORGANIC LETTERS

JF - ORGANIC LETTERS

IS - 16

ER -

Dioscorealides and dioscoreanone, novel cytotoxic naphthofuranoxepins, and 1,4-phenanthraquinone from Dioscorea membranacea Pierre

Abstract

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