King's College London

Research portal

Direct Incorporation of [11C]CO2 into asymmetric [11C]carbonates

Research output: Contribution to journalArticle

Original languageEnglish
Article number7641304
JournalJournal of Chemistry
DOIs
Publication statusPublished - 10 Dec 2018

Documents

King's Authors

Abstract

A novel carbon-11 radiolabelling methodology for the synthesis of the dialkylcarbonate functional group has been developed. The method uses cyclotron-produced short-lived [11C]CO2 (half-life 20.4 min) directly from the cyclotron target in a one-pot synthesis. Alcohol in the presence of base trapped [11C]CO2 efficiently forming an [11C]alkylcarbonate intermediate that subsequently reacted with an alkylchloride producing the di-substituted [11C]carbonate (34% radiochemical yield, determined by radio-HPLC) in 5 minutes from the end of [11C]CO2 cyclotron delivery.

Download statistics

No data available

View graph of relations

© 2018 King's College London | Strand | London WC2R 2LS | England | United Kingdom | Tel +44 (0)20 7836 5454