TY - JOUR
T1 - Direct Incorporation of [11C]CO2 into asymmetric [11C]carbonates
AU - Haji Dheere, Abdul Karim Osman
AU - Bongarzone, Salvatore
AU - Shakir, Dinah
AU - Gee, Antony
PY - 2018/12/10
Y1 - 2018/12/10
N2 - A novel carbon-11 radiolabelling methodology for the synthesis of the dialkylcarbonate functional group has been developed. The method uses cyclotron-produced short-lived [11C]CO2 (half-life 20.4 min) directly from the cyclotron target in a one-pot synthesis. Alcohol in the presence of base trapped [11C]CO2 efficiently forming an [11C]alkylcarbonate intermediate that subsequently reacted with an alkylchloride producing the di-substituted [11C]carbonate (34% radiochemical yield, determined by radio-HPLC) in 5 minutes from the end of [11C]CO2 cyclotron delivery.
AB - A novel carbon-11 radiolabelling methodology for the synthesis of the dialkylcarbonate functional group has been developed. The method uses cyclotron-produced short-lived [11C]CO2 (half-life 20.4 min) directly from the cyclotron target in a one-pot synthesis. Alcohol in the presence of base trapped [11C]CO2 efficiently forming an [11C]alkylcarbonate intermediate that subsequently reacted with an alkylchloride producing the di-substituted [11C]carbonate (34% radiochemical yield, determined by radio-HPLC) in 5 minutes from the end of [11C]CO2 cyclotron delivery.
U2 - 10.1155/2018/7641304
DO - 10.1155/2018/7641304
M3 - Article
SN - 2090-9071
JO - Journal of Chemistry
JF - Journal of Chemistry
M1 - 7641304
ER -