King's College London

Research portal

Direct Lineage Reprogramming: Harnessing Cell Plasticity between Liver and Pancreas

Research output: Contribution to journalReview article

Standard

Direct Lineage Reprogramming: Harnessing Cell Plasticity between Liver and Pancreas. / Ruzittu, Silvia; Willnow, David; Spagnoli, Francesca Maria.

In: Cold Spring Harbor Perspectives In Biology, 26.11.2019.

Research output: Contribution to journalReview article

Harvard

Ruzittu, S, Willnow, D & Spagnoli, FM 2019, 'Direct Lineage Reprogramming: Harnessing Cell Plasticity between Liver and Pancreas', Cold Spring Harbor Perspectives In Biology. https://doi.org/doi:10.1101/cshperspect.a035626

APA

Ruzittu, S., Willnow, D., & Spagnoli, F. M. (2019). Direct Lineage Reprogramming: Harnessing Cell Plasticity between Liver and Pancreas. Cold Spring Harbor Perspectives In Biology. https://doi.org/doi:10.1101/cshperspect.a035626

Vancouver

Ruzittu S, Willnow D, Spagnoli FM. Direct Lineage Reprogramming: Harnessing Cell Plasticity between Liver and Pancreas. Cold Spring Harbor Perspectives In Biology. 2019 Nov 26. https://doi.org/doi:10.1101/cshperspect.a035626

Author

Ruzittu, Silvia ; Willnow, David ; Spagnoli, Francesca Maria. / Direct Lineage Reprogramming: Harnessing Cell Plasticity between Liver and Pancreas. In: Cold Spring Harbor Perspectives In Biology. 2019.

Bibtex Download

@article{6495bca342484aa981ae20384c2cb782,
title = "Direct Lineage Reprogramming: Harnessing Cell Plasticity between Liver and Pancreas",
abstract = "Direct lineage reprogramming of abundant and accessible cells into therapeutically useful cell types holds tremendous potential in regenerative medicine. To date, a number of different cell types have been generated by lineage reprogramming methods, including cells from theneural, cardiac, hepatic, and pancreatic lineages. The success of this strategy relies on developmental biology and the knowledge of cell-fate-defining transcriptional networks.Hepatocytes represent a prime target for β-cell conversion for numerous reasons, including close developmental origin, accessibility, and regenerative potential. We present here an overview of pancreatic and hepatic development, with a particular focus on the mechanisms underlying the divergence between the two cell lineages. Additionally, we discuss to what extent this lineage relationship can be exploited in efforts to reprogram one cell type into theother and whether such an approach may provide a suitable strategy for regenerative therapies of diabetes.",
author = "Silvia Ruzittu and David Willnow and Spagnoli, {Francesca Maria}",
year = "2019",
month = nov,
day = "26",
doi = "doi:10.1101/cshperspect.a035626",
language = "English",
journal = "Cold Spring Harbor Perspectives In Biology",
issn = "1943-0264",
publisher = "Cold Spring Harbor Laboratory Press",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Direct Lineage Reprogramming: Harnessing Cell Plasticity between Liver and Pancreas

AU - Ruzittu, Silvia

AU - Willnow, David

AU - Spagnoli, Francesca Maria

PY - 2019/11/26

Y1 - 2019/11/26

N2 - Direct lineage reprogramming of abundant and accessible cells into therapeutically useful cell types holds tremendous potential in regenerative medicine. To date, a number of different cell types have been generated by lineage reprogramming methods, including cells from theneural, cardiac, hepatic, and pancreatic lineages. The success of this strategy relies on developmental biology and the knowledge of cell-fate-defining transcriptional networks.Hepatocytes represent a prime target for β-cell conversion for numerous reasons, including close developmental origin, accessibility, and regenerative potential. We present here an overview of pancreatic and hepatic development, with a particular focus on the mechanisms underlying the divergence between the two cell lineages. Additionally, we discuss to what extent this lineage relationship can be exploited in efforts to reprogram one cell type into theother and whether such an approach may provide a suitable strategy for regenerative therapies of diabetes.

AB - Direct lineage reprogramming of abundant and accessible cells into therapeutically useful cell types holds tremendous potential in regenerative medicine. To date, a number of different cell types have been generated by lineage reprogramming methods, including cells from theneural, cardiac, hepatic, and pancreatic lineages. The success of this strategy relies on developmental biology and the knowledge of cell-fate-defining transcriptional networks.Hepatocytes represent a prime target for β-cell conversion for numerous reasons, including close developmental origin, accessibility, and regenerative potential. We present here an overview of pancreatic and hepatic development, with a particular focus on the mechanisms underlying the divergence between the two cell lineages. Additionally, we discuss to what extent this lineage relationship can be exploited in efforts to reprogram one cell type into theother and whether such an approach may provide a suitable strategy for regenerative therapies of diabetes.

U2 - doi:10.1101/cshperspect.a035626

DO - doi:10.1101/cshperspect.a035626

M3 - Review article

JO - Cold Spring Harbor Perspectives In Biology

JF - Cold Spring Harbor Perspectives In Biology

SN - 1943-0264

ER -

View graph of relations

© 2020 King's College London | Strand | London WC2R 2LS | England | United Kingdom | Tel +44 (0)20 7836 5454