Disease severity in patients with visceral leishmaniasis is not altered by co-infection with intestinal parasites

Fitsumbrhan Tajebe; Mulusew Getahun; Emebet Adem; Asrat Hailu; Mulualem Lemma; Helina Fikre; John Raynes; Aschalew Tamiru; Zemenay Mulugeta; Ermias Diro; Frederic Toulza; Ziv Shkedy; Tadesse Ayele; Manuel Modolell; Markus Munder; Ingrid Müller; Yegnasew Takele; Pascale Kropf

doi:10.1371/journal.pntd.0005727

Disease severity in patients with visceral leishmaniasis is not altered by co-infection with intestinal parasites

Fitsumbrhan Tajebe, Mulusew Getahun, Emebet Adem, Asrat Hailu, Mulualem Lemma, Helina Fikre, John Raynes, Aschalew Tamiru, Zemenay Mulugeta, Ermias Diro, Frederic Toulza, Ziv Shkedy, Tadesse Ayele, Manuel Modolell, Markus Munder, Ingrid Müller, Yegnasew Takele, Pascale Kropf^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

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Abstract

Visceral leishmaniasis (VL) is a neglected tropical disease that affects the poorest communities and can cause substantial morbidity and mortality. Visceral leishmaniasis is characterized by the presence of Leishmania parasites in the spleen, liver and bone marrow, hepatosplenomegaly, pancytopenia, prolonged fever, systemic inflammation and low body mass index (BMI). The factors impacting on the severity of VL are poorly characterized. Here we performed a cross-sectional study to assess whether co-infection of VL patients with intestinal parasites influences disease severity, assessed with clinical and haematological data, inflammation, cytokine profiles and BMI. Data from VL patients was similar to VL patients co-infected with intestinal parasites, suggesting that co-infection of VL patients with intestinal parasites does not alter disease severity.

Original language	English
Article number	e0005727
Journal	PLoS Neglected Tropical Diseases
Volume	11
Issue number	7
DOIs	https://doi.org/10.1371/journal.pntd.0005727
Publication status	Published - 21 Jul 2017

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Disease severity in patients_TAJEBE_Published2017_GOLD VoR (CC BY)Final published version, 2.03 MBLicence: CC BY

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Tajebe, F., Getahun, M., Adem, E., Hailu, A., Lemma, M., Fikre, H., Raynes, J., Tamiru, A., Mulugeta, Z., Diro, E., Toulza, F., Shkedy, Z., Ayele, T., Modolell, M., Munder, M., Müller, I., Takele, Y., & Kropf, P. (2017). Disease severity in patients with visceral leishmaniasis is not altered by co-infection with intestinal parasites. PLoS Neglected Tropical Diseases, 11(7), Article e0005727. https://doi.org/10.1371/journal.pntd.0005727

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title = "Disease severity in patients with visceral leishmaniasis is not altered by co-infection with intestinal parasites",

abstract = "Visceral leishmaniasis (VL) is a neglected tropical disease that affects the poorest communities and can cause substantial morbidity and mortality. Visceral leishmaniasis is characterized by the presence of Leishmania parasites in the spleen, liver and bone marrow, hepatosplenomegaly, pancytopenia, prolonged fever, systemic inflammation and low body mass index (BMI). The factors impacting on the severity of VL are poorly characterized. Here we performed a cross-sectional study to assess whether co-infection of VL patients with intestinal parasites influences disease severity, assessed with clinical and haematological data, inflammation, cytokine profiles and BMI. Data from VL patients was similar to VL patients co-infected with intestinal parasites, suggesting that co-infection of VL patients with intestinal parasites does not alter disease severity.",

author = "Fitsumbrhan Tajebe and Mulusew Getahun and Emebet Adem and Asrat Hailu and Mulualem Lemma and Helina Fikre and John Raynes and Aschalew Tamiru and Zemenay Mulugeta and Ermias Diro and Frederic Toulza and Ziv Shkedy and Tadesse Ayele and Manuel Modolell and Markus Munder and Ingrid M{\"u}ller and Yegnasew Takele and Pascale Kropf",

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Tajebe, F, Getahun, M, Adem, E, Hailu, A, Lemma, M, Fikre, H, Raynes, J, Tamiru, A, Mulugeta, Z, Diro, E, Toulza, F, Shkedy, Z, Ayele, T, Modolell, M, Munder, M, Müller, I, Takele, Y & Kropf, P 2017, 'Disease severity in patients with visceral leishmaniasis is not altered by co-infection with intestinal parasites', PLoS Neglected Tropical Diseases, vol. 11, no. 7, e0005727. https://doi.org/10.1371/journal.pntd.0005727

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T1 - Disease severity in patients with visceral leishmaniasis is not altered by co-infection with intestinal parasites

AU - Tajebe, Fitsumbrhan

AU - Getahun, Mulusew

AU - Adem, Emebet

AU - Hailu, Asrat

AU - Lemma, Mulualem

AU - Fikre, Helina

AU - Raynes, John

AU - Tamiru, Aschalew

AU - Mulugeta, Zemenay

AU - Diro, Ermias

AU - Toulza, Frederic

AU - Shkedy, Ziv

AU - Ayele, Tadesse

AU - Modolell, Manuel

AU - Munder, Markus

AU - Müller, Ingrid

AU - Takele, Yegnasew

AU - Kropf, Pascale

PY - 2017/7/21

Y1 - 2017/7/21

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AB - Visceral leishmaniasis (VL) is a neglected tropical disease that affects the poorest communities and can cause substantial morbidity and mortality. Visceral leishmaniasis is characterized by the presence of Leishmania parasites in the spleen, liver and bone marrow, hepatosplenomegaly, pancytopenia, prolonged fever, systemic inflammation and low body mass index (BMI). The factors impacting on the severity of VL are poorly characterized. Here we performed a cross-sectional study to assess whether co-infection of VL patients with intestinal parasites influences disease severity, assessed with clinical and haematological data, inflammation, cytokine profiles and BMI. Data from VL patients was similar to VL patients co-infected with intestinal parasites, suggesting that co-infection of VL patients with intestinal parasites does not alter disease severity.

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JF - PLoS Neglected Tropical Diseases

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M1 - e0005727

ER -

Disease severity in patients with visceral leishmaniasis is not altered by co-infection with intestinal parasites

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