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Disengaging polymerase: Terminating RNA polymerase II transcription in budding yeast

Research output: Contribution to journalReview article

Hannah E. Mischo, Nick J. Proudfoot

Original languageEnglish
Pages (from-to)174-185
Number of pages12
JournalBiochimica et Biophysica Acta - Gene Regulatory Mechanisms
Volume1829
Issue number1
Early online date12 Oct 2012
DOIs
Publication statusPublished - 1 Jan 2013

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Abstract

Termination of transcription by RNA polymerase II requires two distinct processes: The formation of a defined 3' end of the transcribed RNA, as well as the disengagement of RNA polymerase from its DNA template. Both processes are intimately connected and equally pivotal in the process of functional messenger RNA production. However, research in recent years has elaborated how both processes can additionally be employed to control gene expression in qualitative and quantitative ways. This review embraces these new findings and attempts to paint a broader picture of how this final step in the transcription cycle is of critical importance to many aspects of gene regulation. This article is part of a Special Issue entitled: RNA polymerase II Transcript Elongation.

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