Disorder-specific functional abnormalities during temporal discounting in youth with Attention Defecit Hyperactivity Disorder(ADHD), Autism and comorbid ADHD and Autism.

Kaylita Charlene Chantiluke; Anastasia Christakou; Clodagh Murphy; Vincent Pierre Giampietro; Eileen M Daly; Christina Ecker; Michael John Brammer; Declan G Murphy; Katya Rubia

doi:10.1016/j.pscychresns.2014.04.006

Disorder-specific functional abnormalities during temporal discounting in youth with Attention Defecit Hyperactivity Disorder(ADHD), Autism and comorbid ADHD and Autism.

Kaylita Charlene Chantiluke, Anastasia Christakou, Clodagh Murphy, Vincent Pierre Giampietro, Eileen M Daly, Christina Ecker, Michael John Brammer, Declan G Murphy, Katya Rubia

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Abstract

Attention Deficit Hyperactivity Disorder (ADHD) and Autism Spectrum Disorder (ASD) are often comorbid and share cognitive abnormalities in temporal foresight. A key question is whether shared cognitive phenotypes are based on common or different underlying pathophysiologies and whether comorbid patients have additive neurofunctional deficits, resemble one of the disorders or have a different pathophysiology. We compared age- and IQ-matched boys with non-comorbid ADHD (18), non-comorbid ASD (15), comorbid ADHD and ASD (13) and healthy controls (18) using functional magnetic resonance imaging (fMRI) during a temporal discounting task. Only the ASD and the comorbid groups discounted delayed rewards more steeply. The fMRI data showed both shared and disorder-specific abnormalities in the three groups relative to controls in their brain-behaviour associations. The comorbid group showed both unique and more severe brain-discounting associations than controls and the non-comorbid patient groups in temporal discounting areas of ventromedial and lateral prefrontal cortex, ventral striatum and anterior cingulate, suggesting that comorbidity is neither an endophenocopy of the two pure disorders nor an additive pathology.

Original language	English
Pages (from-to)	13–120
Number of pages	39
Journal	Psychiatry Research. Neuroimaging
Volume	223
Issue number	2
DOIs	https://doi.org/10.1016/j.pscychresns.2014.04.006
Publication status	Published - 30 Aug 2014

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Chantiluke, K. C., Christakou, A., Murphy, C., Giampietro, V. P., Daly, E. M., Ecker, C., Brammer, M. J., Murphy, D. G., & Rubia, K. (2014). Disorder-specific functional abnormalities during temporal discounting in youth with Attention Defecit Hyperactivity Disorder(ADHD), Autism and comorbid ADHD and Autism. Psychiatry Research. Neuroimaging, 223(2), 13–120. https://doi.org/10.1016/j.pscychresns.2014.04.006

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title = "Disorder-specific functional abnormalities during temporal discounting in youth with Attention Defecit Hyperactivity Disorder(ADHD), Autism and comorbid ADHD and Autism.",

abstract = "Attention Deficit Hyperactivity Disorder (ADHD) and Autism Spectrum Disorder (ASD) are often comorbid and share cognitive abnormalities in temporal foresight. A key question is whether shared cognitive phenotypes are based on common or different underlying pathophysiologies and whether comorbid patients have additive neurofunctional deficits, resemble one of the disorders or have a different pathophysiology. We compared age- and IQ-matched boys with non-comorbid ADHD (18), non-comorbid ASD (15), comorbid ADHD and ASD (13) and healthy controls (18) using functional magnetic resonance imaging (fMRI) during a temporal discounting task. Only the ASD and the comorbid groups discounted delayed rewards more steeply. The fMRI data showed both shared and disorder-specific abnormalities in the three groups relative to controls in their brain-behaviour associations. The comorbid group showed both unique and more severe brain-discounting associations than controls and the non-comorbid patient groups in temporal discounting areas of ventromedial and lateral prefrontal cortex, ventral striatum and anterior cingulate, suggesting that comorbidity is neither an endophenocopy of the two pure disorders nor an additive pathology.",

author = "Chantiluke, {Kaylita Charlene} and Anastasia Christakou and Clodagh Murphy and Giampietro, {Vincent Pierre} and Daly, {Eileen M} and Christina Ecker and Brammer, {Michael John} and Murphy, {Declan G} and Katya Rubia",

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language = "English",

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Chantiluke, KC , Christakou, A , Murphy, C , Giampietro, VP , Daly, EM, Ecker, C, Brammer, MJ , Murphy, DG & Rubia, K 2014, 'Disorder-specific functional abnormalities during temporal discounting in youth with Attention Defecit Hyperactivity Disorder(ADHD), Autism and comorbid ADHD and Autism.', Psychiatry Research. Neuroimaging, vol. 223, no. 2, pp. 13–120. https://doi.org/10.1016/j.pscychresns.2014.04.006

Disorder-specific functional abnormalities during temporal discounting in youth with Attention Defecit Hyperactivity Disorder(ADHD), Autism and comorbid ADHD and Autism. / Chantiluke, Kaylita Charlene ; Christakou, Anastasia ; Murphy, Clodagh et al.
In: Psychiatry Research. Neuroimaging, Vol. 223, No. 2, 30.08.2014, p. 13–120.

Research output: Contribution to journal › Article › peer-review

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AU - Chantiluke, Kaylita Charlene

AU - Christakou, Anastasia

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AU - Giampietro, Vincent Pierre

AU - Daly, Eileen M

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AU - Rubia, Katya

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N2 - Attention Deficit Hyperactivity Disorder (ADHD) and Autism Spectrum Disorder (ASD) are often comorbid and share cognitive abnormalities in temporal foresight. A key question is whether shared cognitive phenotypes are based on common or different underlying pathophysiologies and whether comorbid patients have additive neurofunctional deficits, resemble one of the disorders or have a different pathophysiology. We compared age- and IQ-matched boys with non-comorbid ADHD (18), non-comorbid ASD (15), comorbid ADHD and ASD (13) and healthy controls (18) using functional magnetic resonance imaging (fMRI) during a temporal discounting task. Only the ASD and the comorbid groups discounted delayed rewards more steeply. The fMRI data showed both shared and disorder-specific abnormalities in the three groups relative to controls in their brain-behaviour associations. The comorbid group showed both unique and more severe brain-discounting associations than controls and the non-comorbid patient groups in temporal discounting areas of ventromedial and lateral prefrontal cortex, ventral striatum and anterior cingulate, suggesting that comorbidity is neither an endophenocopy of the two pure disorders nor an additive pathology.

AB - Attention Deficit Hyperactivity Disorder (ADHD) and Autism Spectrum Disorder (ASD) are often comorbid and share cognitive abnormalities in temporal foresight. A key question is whether shared cognitive phenotypes are based on common or different underlying pathophysiologies and whether comorbid patients have additive neurofunctional deficits, resemble one of the disorders or have a different pathophysiology. We compared age- and IQ-matched boys with non-comorbid ADHD (18), non-comorbid ASD (15), comorbid ADHD and ASD (13) and healthy controls (18) using functional magnetic resonance imaging (fMRI) during a temporal discounting task. Only the ASD and the comorbid groups discounted delayed rewards more steeply. The fMRI data showed both shared and disorder-specific abnormalities in the three groups relative to controls in their brain-behaviour associations. The comorbid group showed both unique and more severe brain-discounting associations than controls and the non-comorbid patient groups in temporal discounting areas of ventromedial and lateral prefrontal cortex, ventral striatum and anterior cingulate, suggesting that comorbidity is neither an endophenocopy of the two pure disorders nor an additive pathology.

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ER -

Disorder-specific functional abnormalities during temporal discounting in youth with Attention Defecit Hyperactivity Disorder(ADHD), Autism and comorbid ADHD and Autism.

Abstract

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