King's College London

Research portal

Disproportionate cardiac hypertrophy during early postnatal development in infants born preterm

Research output: Contribution to journalArticle

Standard

Disproportionate cardiac hypertrophy during early postnatal development in infants born preterm. / Aye, Christina Y L; Lewandowski, Adam J; Lamata de la Orden, Pablo; Upton, Ross; Davis, E; Ohuma, Eric O; Kenworthy, Yvonne; Boardman, Henry; Wopperer, Samuel; Packham, Alice; Adwani, Satish; McCormick, Kenny; Papageorghiou, Aris T; Leeson, Paul.

In: Pediatric Research, Vol. 82, No. 1, 01.07.2017, p. 36-46.

Research output: Contribution to journalArticle

Harvard

Aye, CYL, Lewandowski, AJ, Lamata de la Orden, P, Upton, R, Davis, E, Ohuma, EO, Kenworthy, Y, Boardman, H, Wopperer, S, Packham, A, Adwani, S, McCormick, K, Papageorghiou, AT & Leeson, P 2017, 'Disproportionate cardiac hypertrophy during early postnatal development in infants born preterm' Pediatric Research, vol. 82, no. 1, pp. 36-46. DOI: 10.1038/pr.2017.96

APA

Aye, C. Y. L., Lewandowski, A. J., Lamata de la Orden, P., Upton, R., Davis, E., Ohuma, E. O., ... Leeson, P. (2017). Disproportionate cardiac hypertrophy during early postnatal development in infants born preterm. DOI: 10.1038/pr.2017.96

Vancouver

Aye CYL, Lewandowski AJ, Lamata de la Orden P, Upton R, Davis E, Ohuma EO et al. Disproportionate cardiac hypertrophy during early postnatal development in infants born preterm. Pediatric Research. 2017 Jul 1;82(1):36-46. Available from, DOI: 10.1038/pr.2017.96

Author

Aye, Christina Y L ; Lewandowski, Adam J ; Lamata de la Orden, Pablo ; Upton, Ross ; Davis, E ; Ohuma, Eric O ; Kenworthy, Yvonne ; Boardman, Henry ; Wopperer, Samuel ; Packham, Alice ; Adwani, Satish ; McCormick, Kenny ; Papageorghiou, Aris T ; Leeson, Paul. / Disproportionate cardiac hypertrophy during early postnatal development in infants born preterm. In: Pediatric Research. 2017 ; Vol. 82, No. 1. pp. 36-46

Bibtex Download

@article{8ffaac61aff24203a9b5cbdb96058b18,
title = "Disproportionate cardiac hypertrophy during early postnatal development in infants born preterm",
abstract = "Background Adults born very preterm have increased cardiac mass and reduced function. We investigated whether a hypertrophic phenomenon occurs in later preterm infants and when this occurs during early development. Methods Cardiac ultrasound was performed on 392 infants (33{\%} preterm at mean gestation 34±2 weeks). Scans were performed during fetal development in 137, at birth and 3 months of postnatal age in 200, and during both fetal and postnatal development in 55. Cardiac morphology and function was quantified and computational models created to identify geometric changes. Results At birth, preterm offspring had reduced cardiac mass and volume relative to body size with a more globular heart. By 3 months, ventricular shape had normalized but both left and right ventricular mass relative to body size were significantly higher than expected for postmenstrual age (left 57.8±41.9 vs. 27.3±29.4{\%}, P<0.001; right 39.3±38.1 vs. 16.6±40.8, P=0.002). Greater changes were associated with lower gestational age at birth (left P<0.001; right P=0.001). Conclusion Preterm offspring, including those born in late gestation, have a disproportionate increase in ventricular mass from birth up to 3 months of postnatal age. These differences were not present before birth. Early postnatal development may provide a window for interventions relevant to long-term cardiovascular health.",
author = "Aye, {Christina Y L} and Lewandowski, {Adam J} and {Lamata de la Orden}, Pablo and Ross Upton and E Davis and Ohuma, {Eric O} and Yvonne Kenworthy and Henry Boardman and Samuel Wopperer and Alice Packham and Satish Adwani and Kenny McCormick and Papageorghiou, {Aris T} and Paul Leeson",
year = "2017",
month = "7",
day = "1",
doi = "10.1038/pr.2017.96",
language = "English",
volume = "82",
pages = "36--46",
journal = "Pediatric Research",
issn = "0031-3998",
publisher = "Lippincott Williams and Wilkins",
number = "1",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Disproportionate cardiac hypertrophy during early postnatal development in infants born preterm

AU - Aye,Christina Y L

AU - Lewandowski,Adam J

AU - Lamata de la Orden,Pablo

AU - Upton,Ross

AU - Davis,E

AU - Ohuma,Eric O

AU - Kenworthy,Yvonne

AU - Boardman,Henry

AU - Wopperer,Samuel

AU - Packham,Alice

AU - Adwani,Satish

AU - McCormick,Kenny

AU - Papageorghiou,Aris T

AU - Leeson,Paul

PY - 2017/7/1

Y1 - 2017/7/1

N2 - Background Adults born very preterm have increased cardiac mass and reduced function. We investigated whether a hypertrophic phenomenon occurs in later preterm infants and when this occurs during early development. Methods Cardiac ultrasound was performed on 392 infants (33% preterm at mean gestation 34±2 weeks). Scans were performed during fetal development in 137, at birth and 3 months of postnatal age in 200, and during both fetal and postnatal development in 55. Cardiac morphology and function was quantified and computational models created to identify geometric changes. Results At birth, preterm offspring had reduced cardiac mass and volume relative to body size with a more globular heart. By 3 months, ventricular shape had normalized but both left and right ventricular mass relative to body size were significantly higher than expected for postmenstrual age (left 57.8±41.9 vs. 27.3±29.4%, P<0.001; right 39.3±38.1 vs. 16.6±40.8, P=0.002). Greater changes were associated with lower gestational age at birth (left P<0.001; right P=0.001). Conclusion Preterm offspring, including those born in late gestation, have a disproportionate increase in ventricular mass from birth up to 3 months of postnatal age. These differences were not present before birth. Early postnatal development may provide a window for interventions relevant to long-term cardiovascular health.

AB - Background Adults born very preterm have increased cardiac mass and reduced function. We investigated whether a hypertrophic phenomenon occurs in later preterm infants and when this occurs during early development. Methods Cardiac ultrasound was performed on 392 infants (33% preterm at mean gestation 34±2 weeks). Scans were performed during fetal development in 137, at birth and 3 months of postnatal age in 200, and during both fetal and postnatal development in 55. Cardiac morphology and function was quantified and computational models created to identify geometric changes. Results At birth, preterm offspring had reduced cardiac mass and volume relative to body size with a more globular heart. By 3 months, ventricular shape had normalized but both left and right ventricular mass relative to body size were significantly higher than expected for postmenstrual age (left 57.8±41.9 vs. 27.3±29.4%, P<0.001; right 39.3±38.1 vs. 16.6±40.8, P=0.002). Greater changes were associated with lower gestational age at birth (left P<0.001; right P=0.001). Conclusion Preterm offspring, including those born in late gestation, have a disproportionate increase in ventricular mass from birth up to 3 months of postnatal age. These differences were not present before birth. Early postnatal development may provide a window for interventions relevant to long-term cardiovascular health.

U2 - 10.1038/pr.2017.96

DO - 10.1038/pr.2017.96

M3 - Article

VL - 82

SP - 36

EP - 46

JO - Pediatric Research

T2 - Pediatric Research

JF - Pediatric Research

SN - 0031-3998

IS - 1

ER -

View graph of relations

© 2018 King's College London | Strand | London WC2R 2LS | England | United Kingdom | Tel +44 (0)20 7836 5454