Disrupted prediction-error signal in psychosis: evidence for an associative account of delusions

P. R. Corlett; G. K. Murray; G. D. Honey; M. R. F. Aitken; D. R. Shanks; T. W. Robbins; E. T. Bullmore; A. Dickinson; P. C. Fletcher

doi:10.1093/brain/awm173

Disrupted prediction-error signal in psychosis: evidence for an associative account of delusions

P. R. Corlett, G. K. Murray, G. D. Honey, M. R. F. Aitken, D. R. Shanks, T. W. Robbins, E. T. Bullmore, A. Dickinson, P. C. Fletcher^*

^*Corresponding author for this work

University of Cambridge

Research output: Contribution to journal › Article › peer-review

352 Citations (Scopus)

Abstract

Delusions are maladaptive beliefs about the world. Based upon experimental evidence that prediction error a mismatch between expectancy and outcome drives belief formation, this study examined the possibility that delusions form because of disrupted prediction-error processing. We used fMRI to determine prediction-error-related brain responses in 12 healthy subjects and 12 individuals ( 7 males) with delusional beliefs. Frontal cortex responses in the patient group were suggestive of disrupted prediction-error processing. Furthermore, across subjects, the extent of disruption was significantly related to an individual's propensity to delusion formation. Our results support a neurobiological theory of delusion formation that implicates aberrant prediction-error signalling, disrupted attentional allocation and associative learning in the formation of delusional beliefs.

Original language	English
Pages (from-to)	2387-2400
Number of pages	14
Journal	Brain research
Volume	130
Issue number	9
DOIs	https://doi.org/10.1093/brain/awm173
Publication status	Published - Sept 2007

Keywords

prediction error
associative learning
fMRI
delusions
psychosis
NMDA RECEPTOR HYPOFUNCTION
PREFRONTAL CORTEX
EXECUTIVE FUNCTION
FRONTOSTRIATAL DYSFUNCTION
RETROSPECTIVE REVALUATION
DOPAMINE HYPOTHESIS
COGNITIVE CONTROL
LEARNING-THEORY
FRONTAL-CORTEX
MOUSE BRAIN

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title = "Disrupted prediction-error signal in psychosis: evidence for an associative account of delusions",

abstract = "Delusions are maladaptive beliefs about the world. Based upon experimental evidence that prediction error a mismatch between expectancy and outcome drives belief formation, this study examined the possibility that delusions form because of disrupted prediction-error processing. We used fMRI to determine prediction-error-related brain responses in 12 healthy subjects and 12 individuals ( 7 males) with delusional beliefs. Frontal cortex responses in the patient group were suggestive of disrupted prediction-error processing. Furthermore, across subjects, the extent of disruption was significantly related to an individual's propensity to delusion formation. Our results support a neurobiological theory of delusion formation that implicates aberrant prediction-error signalling, disrupted attentional allocation and associative learning in the formation of delusional beliefs.",

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author = "Corlett, {P. R.} and Murray, {G. K.} and Honey, {G. D.} and Aitken, {M. R. F.} and Shanks, {D. R.} and Robbins, {T. W.} and Bullmore, {E. T.} and A. Dickinson and Fletcher, {P. C.}",

year = "2007",

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doi = "10.1093/brain/awm173",

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T2 - evidence for an associative account of delusions

AU - Corlett, P. R.

AU - Murray, G. K.

AU - Honey, G. D.

AU - Aitken, M. R. F.

AU - Shanks, D. R.

AU - Robbins, T. W.

AU - Bullmore, E. T.

AU - Dickinson, A.

AU - Fletcher, P. C.

PY - 2007/9

Y1 - 2007/9

N2 - Delusions are maladaptive beliefs about the world. Based upon experimental evidence that prediction error a mismatch between expectancy and outcome drives belief formation, this study examined the possibility that delusions form because of disrupted prediction-error processing. We used fMRI to determine prediction-error-related brain responses in 12 healthy subjects and 12 individuals ( 7 males) with delusional beliefs. Frontal cortex responses in the patient group were suggestive of disrupted prediction-error processing. Furthermore, across subjects, the extent of disruption was significantly related to an individual's propensity to delusion formation. Our results support a neurobiological theory of delusion formation that implicates aberrant prediction-error signalling, disrupted attentional allocation and associative learning in the formation of delusional beliefs.

AB - Delusions are maladaptive beliefs about the world. Based upon experimental evidence that prediction error a mismatch between expectancy and outcome drives belief formation, this study examined the possibility that delusions form because of disrupted prediction-error processing. We used fMRI to determine prediction-error-related brain responses in 12 healthy subjects and 12 individuals ( 7 males) with delusional beliefs. Frontal cortex responses in the patient group were suggestive of disrupted prediction-error processing. Furthermore, across subjects, the extent of disruption was significantly related to an individual's propensity to delusion formation. Our results support a neurobiological theory of delusion formation that implicates aberrant prediction-error signalling, disrupted attentional allocation and associative learning in the formation of delusional beliefs.

KW - prediction error

KW - associative learning

KW - fMRI

KW - delusions

KW - psychosis

KW - NMDA RECEPTOR HYPOFUNCTION

KW - PREFRONTAL CORTEX

KW - EXECUTIVE FUNCTION

KW - FRONTOSTRIATAL DYSFUNCTION

KW - RETROSPECTIVE REVALUATION

KW - DOPAMINE HYPOTHESIS

KW - COGNITIVE CONTROL

KW - LEARNING-THEORY

KW - FRONTAL-CORTEX

KW - MOUSE BRAIN

U2 - 10.1093/brain/awm173

DO - 10.1093/brain/awm173

M3 - Article

SN - 0006-8950

VL - 130

SP - 2387

EP - 2400

JO - Brain research

JF - Brain research

IS - 9

ER -

Disrupted prediction-error signal in psychosis: evidence for an associative account of delusions

Abstract

Keywords

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