Research output: Contribution to journal › Article › peer-review
Federica La Russa, Douglas M. Lopes, Carl Hobbs, Fulye Argunhan, Susan Brain, Stuart Bevan, David L.H. Bennett, Stephen B. McMahon
Original language | English |
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Pages (from-to) | 1936-1945.e3 |
Journal | Journal of Investigative Dermatology |
Volume | 139 |
Issue number | 9 |
Early online date | 8 Apr 2019 |
DOIs | |
Accepted/In press | 12 Jan 2019 |
E-pub ahead of print | 8 Apr 2019 |
Published | Sep 2019 |
Additional links |
Disruption of the Sensory_RUSSA_Accepted12Jan2019_GREEN AAM
La_Russa_et_al._for_open_access_.pdf, 1.3 MB, application/pdf
Uploaded date:19 Dec 2019
Version:Accepted author manuscript
Licence:CC BY-NC-ND
Increasing evidence suggests that nerve fibers responding to noxious stimuli (nociceptors) modulate immunity in a variety of tissues, including the skin. Yet, the role of nociceptors in regulating sterile cutaneous inflammation remains unexplored. To address this question, we have developed a detailed description of the sterile inflammation caused by overexposure to UVB irradiation (i.e., sunburn) in the mouse plantar skin. Using this model, we observed that chemical depletion of nociceptor terminals did not alter the early phase of the inflammatory response to UVB, but it caused a significant increase in the number of dendritic cells and αβ + T cells as well as enhanced extravasation during the later stages of inflammation. Finally, we showed that such regulation was driven by the nociceptive neuropeptide calcitonin gene–related peptide. In conclusion, we propose that nociceptors not only play a crucial role in inflammation through avoidance reflexes and behaviors, but can also regulate sterile cutaneous immunity in vivo.
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